Ann Van den Bruel
Senior Clinical Research Fellow
- Director NIHR Diagnostic Evidence Cooperative Oxford
My research focuses on diagnostic tests.
Diagnostic tests help doctors to identify illnesses and other conditions so that patients may be treated or given a prognosis about the course of the illness. It is important to study the added value of tests because a better understanding leads to more efficient healthcare and better outcomes for patients.
Over the past years, I have worked mainly on the diagnosis of serious infections in children. More precisely I conducted a large-scale study in primary care to analyse the value of clinical features for this diagnosis. In addition, we looked at how laboratory tests can help with this diagnosis, and how parents and doctors view the diagnostic process when a child is admitted to hospital with a serious infection. The results of these studies have been used in several guidelines including one on feverish children by NICE.
More generally, I have collaborated with colleagues in other studies on diagnostic tests, such as clinial features in patients with chest pain, ultrasound for patients with shoulder problems, exercise testing to identify coronary disease, etc.
Currently I am the Director of the NIHR Diagnostic Evidence Cooperative Oxford which aims to facilitate diagnostic innovations in the NHS. We offer training and advice for anyone who is developing a new diagnostic test for primary care.
In addition to research, I'm also involved in teaching for the Centre for Evidence Based Medicine and other institutions across Europe.
Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.
Thompson M. et al, (2012), Health Technol Assess, 16, 1 - 100
Clinicians' gut feeling about serious infections in children: observational study.
Van den Bruel A. et al, (2012), Bmj, 345
Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review.
Van den Bruel A. et al, (2011), Bmj, 342
Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review.
Van den Bruel A. et al, (2010), Lancet, 375, 834 - 845
The evaluation of diagnostic tests: evidence on technical and diagnostic accuracy, impact on patient outcome and cost-effectiveness is needed.
Van den Bruel A. et al, (2007), J Clin Epidemiol, 60, 1116 - 1122
Validity and reliability of measurement of capillary refill time in children: a systematic review.
Fleming S. et al, (2014), Arch Dis Child
Research into practice: acutely ill children.
Van den Bruel A. and Thompson M., (2014), Br J Gen Pract, 64, 311 - 313
Response to Donner-Banzhoff
Van Den Bruel A. and Perera R., (2014), Journal of Clinical Epidemiology, 67, 137 - 137
The comprehensive diagnostic study: A new solution to old problems?
Van Den Bruel A. and Perera R., (2014), Journal of Clinical Epidemiology, 67, 133 - 134
Response to Donner-Banzhoff.
van den Bruel A. and Perera R., (2014), J Clin Epidemiol, 67