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Areas of research interest: TIA/Stroke, chronic kidney disease, derivation and validation of clinical prediction rules, optimal acute care pathways at the interface between primary and secondary care
Research methods: Population-based epidemiology, cohort studies, randomised controlled trials, large database analysis.
MA MBBS(Hons) MD FRCP Edin MRCGP
- Theme Co - Lead, Prevention and Population Care, NIHR Oxford Biomedical Research Centre
- Chair, NIHR Stroke Research Network Primary Care Clinical Studies Group
- Lead, Out of Hospital Care Network, Oxford Academic Health Science Network
- Senior Trust General Practitioner, Department of Geratology, Oxford University Hospitals NHS Trust
- Member of SAPC Executive Committee
- Department lead for NIHR academic clinical training
My research looks at ways to reduce cardiovascular events in general practice. This is important because stroke and heart disease are the commonest causes of death and chronic disease burden. My research projects are in two major areas – stroke prevention and chronic kidney disease.
The stroke prevention work examines how we can improve the recognition of transient ischaemic attack (TIA) in primary care. Patients usually feel well after a TIA but they are at high risk of a stroke, and so accurate recognition is crucial. Healthcare systems in different countries have evolved different approaches to investigation and initiation of treatment of patients with TIA and I am collaborating with GPs and neurologists in the UK, Australia, New Zealand and North Carolina in the US to find the best care process to reduce the risk of stroke.
The chronic kidney disease (CKD) projects examine how we can best diagnose CKD, determine which patients are at increased cardiovascular risk and which treatments reduce cardiac risk and decline in renal function.
These projects will have an impact on clinical work with greater accuracy of detecting patients who need urgent assessment after TIA and determining which patients with a diagnosis of CKD will benefit from additional medication.
Validation of a TIA recognition tool in primary and secondary care: implications for generalizability.
Lasserson DS. et al, (2013), Int J Stroke
Chronic kidney disease: a large-scale population-based study of the effects of introducing the CKD-EPI formula for eGFR reporting.
O'Callaghan CA. et al, (2011), Bmj Open, 1
How quickly should we titrate antihypertensive medication? Systematic review modelling blood pressure response from trial data
Lasserson DS. et al, (2011), Heart, 97, 1771 - 1775
Population-based study of behavior immediately after transient ischemic attack and minor stroke in 1000 consecutive patients: lessons for public education.
Chandratheva A. et al, (2010), Stroke, 41, 1108 - 1114
Influence of general practice opening hours on delay in seeking medical attention after transient ischaemic attack (TIA) and minor stroke: prospective population based study.
Lasserson DS. et al, (2008), Bmj (Clinical Research Ed.), 337
Absolute cardiovascular risk and GP decision making in TIA and minor stroke.
Clarey J. et al, (2014), Fam Pract
Clinical prediction rules in practice: review of clinical guidelines and survey of GPs.
Plüddemann A. et al, (2014), Br J Gen Pract, 64, e233 - e242
Which features of primary care affect unscheduled secondary care use? A systematic review.
Huntley A. et al, (2014), Bmj Open, 4
Life interrupted and life regained? Coping with stroke at a young age.
Kuluski K. et al, (2014), Int J Qual Stud Health Well-being, 9
Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) trial-a multi-centre, prospective, randomised, open, blinded end-point, 36-month study of 2,616 patients within primary care with stage 3b chronic kidney disease to compare the efficacy of spironolactone 25 mg once daily in addition to routine care on mortality and cardiovascular outcomes versus routine care alone: study protocol for a randomized controlled trial.
Hill NR. et al, (2014), Trials, 15