Standardising definitions for the pre-eclampsia core outcome set: A consensus development study
Duffy JMN., Cairns AE., Magee LA., von Dadelszen P., van 't Hooft J., Gale C., Brown M., Chappell LC., Grobman WA., Fitzpatrick R., Karumanchi SA., Lucas DN., Mol B., Stark M., Thangaratinam S., Wilson MJ., Williamson PR., Ziebland S., McManus RJ., Abalos EJ., Adamson CCD., Akadri AA., Akturk Z., Allegaert K., Angel-Müller E., Antretter J., Ashdown HF., Audibert F., Auger N., Aygun C., Babic I., Bagga R., Baker JM., Beebeejaun Y., Bhakta P., Bhandari V., Bhattacharya S., Blanker MH., Bloomfield FH., Bof A., Brennan SM., Broekhuijsen K., Broughton Pipkin F., Browne JL., Browning RM., Bull JW., Butt A., Button D., Campbell JP., Campbell DM., Carbillon L., Carthy S., Casely E., Cave JA., Cecatti JG., Chamillard ME., Chassard D., Checheir NC., Chulkov VS., Cluver CA., Crawford CF., Daly MC., Darmochwal-Kolarz DA., Davies RE., Davies MW., Dawson JS., Dobson N., Dodd CN., Donald F., Duley L., Epstein-Mares J., Erez O., Evans E., Farlie RN., Ferris AV., Frankland EM., Freeman DJ., Gainder S., Ganzevoort W., Gbinigie OA., Gerval MO., Ghosh SK., Gingel LJ., Glogowska M., Goodlife A., Gough KL., Green JR., Gul F., Haggerty L., Hall DR., Hallman M., Hamilton LM., Hammond SJ., Harlow SD., Hays KE., Hickey SC., Higgins M., Hinton L., Hobson SR., Hogg MJ.
© 2020 International Society for the Study of Hypertension in Pregnancy Objectives: To develop consensus definitions for the core outcome set for pre-eclampsia. Study design: Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group. Results: Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring. Conclusions: Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice. Video abstract can be available at: www.dropbox.com/s/ftrgvrfu0u9glqd/6.%20Standardising%20definitions%20in%20teh%20pre-eclampsia%20core%20outcome%20set%3A%20a%20consensus%20development%20study.mp4?dl=0.