{ "items": [ "\n\n
Depression is a very common and impairing condition. Current treatments include antidepressant medication and psychological therapy. Both can be effective, but more than one-third of people do not benefit from these treatments. There are reasons to think that poor sleep is an important contributor to depression, and that if sleep could be improved, depression would improve too. \r\nPrevious research has shown that we can improve sleep quality using a behavioural treatment called \u2018sleep restriction therapy\u2019. This treatment involves reviewing the patient\u2019s current sleep pattern and supporting them to follow a new, personalised sleep schedule. We want to find out whether using this treatment to improve sleep will also improve depression and, if so, how it works.
\n \n\n \n \nPRUDENCE Trial
\n \n\n \n \nEvaluating potential treatments for COVID-19 infection in older people.
\n \n\n \n \nThis study is being carried out by researchers at general practices and hospitals worldwide to collect more information to support the development of a vaccine to prevent serious E-coli infections.
\n \n\n \n \nProspective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli (ExPEC) Isolated from Hospitalized Patients Aged 60 Years or Older with Invasive ExPEC Disease (IED) and to Evaluate the Clinical Case Definition.
\n \n\n \n \nThis study aims to develop and test a better approach to assessing the likely cause (diagnosis) and future outcome (prognosis) of shoulder problems (pain).
\n \n\n \n \nPenicillin allergy status and its effect on antimicrobial prescribing, patient outcomes, and antimicrobial resistance.
\n \n\n \n \nCommunity acquired acute respiratory tract infection (CA-ARTI) in community care in Europe: point prevalence audit study (PPAS) of presentation and management.
\n \n\n \n \nA pragmatic, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy for insomnia disorder to sleep hygiene in primary care.
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