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Depression is a very common and impairing condition. Current treatments include antidepressant medication and psychological therapy. Both can be effective, but more than one-third of people do not benefit from these treatments. There are reasons to think that poor sleep is an important contributor to depression, and that if sleep could be improved, depression would improve too. Previous research has shown that we can improve sleep quality using a behavioural treatment called ‘sleep restriction therapy’. This treatment involves reviewing the patient’s current sleep pattern and supporting them to follow a new, personalised sleep schedule. We want to find out whether using this treatment to improve sleep will also improve depression and, if so, how it works.
Digital alerting to improve sepsis detection and patient outcomes in NHS Trusts: a qualitative study (DiAlS Qual). The DiAlS study will investigate the impact of digital sepsis alerts on patient outcomes and staff activity in NHS hospital Trusts across England and Wales. As UK hospitals move from paper based to electronic health records, the integration of digital alerts to identify patients at risk of deterioration has also become common.
Evaluating potential treatments for COVID-19 infection in older people.
EXPECT-1: Pilot Study to Assess Success Factors and Barriers for Preparation of a Phase 3 Study with ExPEC10V in Adults Aged 60 Years or Older and in Stable Health
This study is being carried out by researchers at general practices and hospitals worldwide to collect more information to support the development of a vaccine to prevent serious E-coli infections.
EXPECT-2: Prospective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli
Prospective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli (ExPEC) Isolated from Hospitalized Patients Aged 60 Years or Older with Invasive ExPEC Disease (IED) and to Evaluate the Clinical Case Definition.
This study aims to develop and test a better approach to assessing the likely cause (diagnosis) and future outcome (prognosis) of shoulder problems (pain).
Penicillin allergy status and its effect on antimicrobial prescribing, patient outcomes, and antimicrobial resistance.
Community acquired acute respiratory tract infection (CA-ARTI) in community care in Europe: point prevalence audit study (PPAS) of presentation and management.
A pragmatic, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy for insomnia disorder to sleep hygiene in primary care.