Trial portfolio
We co-ordinate studies in three main themes, which are aligned with the departmental priorities on infectious diseases, cardiovascular and metabolic disease and health behaviours in addition to other topics of major national and international importance. Find out more about our current portfolio below, or our completed studies.
Cardiovascular & metabolic:
Our clinical research aims to find out which patients are at risk of chronic kidney disease, how their cardiovascular health is affected by this and how screening and monitoring can help.
Infections & acute care:
We are running trials to investigate treatments other than antibiotics for patients presenting with common cough and cold symptoms. This may give GPs and patients treatment options other than antibiotics to help relieve symptoms for these common illnesses.
Health behaviours & other conditions:
We conduct clinical trials offering support to patients regarding weight management and smoking cessation. Better support for behaviour changes can prevent the development of more serious health problems resulting in long-term benefits for patients and the NHS.
Cardiovascular & metabolic
BARACK-D
Benefits of aldosterone receptor antagonism in chronic kidney disease
The BUMP Trial - Blood pressure monitoring in pregnancy
The BUMP trial is testing whether monitoring blood pressure at home during pregnancy can help the early detection of hypertension and pre-eclampsia.
V-TEC
An observational study to determine the incidence of venous thromboembolism among care home residents
HOME-BP
Home and online management and evaluation of blood pressure
OPTiMISE
OPtimising Treatment for MIld Systolic hypertension in the Elderly
OptimiseHFpEF
Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care
OxRen
Oxford renal longitudinal cohort study
FORM -2C
Frequency of renal monitoring - cystatin-C and creatinine study
SNAP-HT
Self-management of postnatal anti-hypertensive treatment trial development pilot study
NewKI
New onset Kidney Impairment Study
SPIRE
Randomised clinical trial of Bococizumab in subjects with hyperlipidemia or mixed dyslipidemia at risk of cardiovascular events.
StAR2D
SMS supporting treatment for people with type 2 diabetes
TASMINH4
Telemonitoring and/or self-monitoring of blood pressure in hypertension
SuMMiT-D
Support through mobile messaging and digital health technology for diabetes
In set-up
UDIP
OXREN II
OPTIMIZE HF
TASMINH5
Infections & acute care
ARCHIE
The early use of antibiotics for ‘at risk’ children with influenza
MERIT
d-MannosE to prevent Recurrent urine InfecTions. Using a naturally occurring sugar d-Mannose to treat recurrent urinary tract infections.
MERMAIDS
Acute respiratory infections in adults
PACE
Point of care testing to target antibiotics for chronic obstructive pulmonary disease exacerbations
PRINCESS
Probiotics to reduce infections in care home residents, the PRINCESS trial
RIVET
Re-inventing influenza vaccine efficacy trials
ATAFUTI
Alternative treatments of adult female urinary tract infection: a double blind, placebo controlled, factorial randomised trial
CONDUCT
Can urine collection devices reduce the chances of contamination?
CRP pilot
A pilot study on the effects of adding c-reactive protein (CRP) point-of-care testing in the management of acutely ill children in primary care
HEAT
Helicobacter eradication to prevent ulcer bleeding in aspirin users trial
In set-up
ALABAMA
Health behaviours & other conditions
HABIT
Health professional Administered Brief Insomnia Therapy (HABIT) trial. A pragmatic, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy for insomnia disorder to sleep hygiene in primary care.
The DIAMOND study
Dietary approaches to the management of type 2 diabetes
Online Weight Loss Study
Testing the short-term effectiveness of online weight loss programmes
MaSC
Brief interventions to support the management of smoking in primary care: a randomised controlled trial
TARS
The aim of the study is to investigate whether Health Trainer support is better at helping people to quit smoking for longer, compared with existing support.
In set-up
PANDA-S