Trial portfolio

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We co-ordinate studies in three main themes, which are aligned with the departmental priorities on infectious diseases, cardiovascular and metabolic disease and health behaviours in addition to other topics of major national and international importance. Find out more about our current portfolio below, or our completed studies.

Cardiovascular & metabolic:

Our clinical research aims to find out which patients are at risk of chronic kidney disease, how their cardiovascular health is affected by this and how screening and monitoring can help.

Infections & acute care:

We are running trials to investigate treatments other than antibiotics for patients presenting with common cough and cold symptoms. This may give GPs and patients treatment options other than antibiotics to help relieve symptoms for these common illnesses.

Health behaviours & other conditions:

We conduct clinical trials offering support to patients regarding weight management and smoking cessation. Better support for behaviour changes can prevent the development of more serious health problems resulting in long-term benefits for patients and the NHS.

Cardiovascular & metabolic

  • BARACK-D

    Benefits of aldosterone receptor antagonism in chronic kidney disease

  • The BUMP Trial - Blood pressure monitoring in pregnancy

    The BUMP trial is testing whether monitoring blood pressure at home during pregnancy can help the early detection of hypertension and pre-eclampsia.

  • COMET

    Near-patient testing to guide COPD maintenance treatment in primary care

  • FORM -2C

    Frequency of renal monitoring - cystatin-C and creatinine study

  • SNAP-HT

    Self-management of postnatal anti-hypertensive treatment trial development pilot study

  • NewKI

    New onset Kidney Impairment Study

  • SPIRE

    Randomised clinical trial of Bococizumab in subjects with hyperlipidemia or mixed dyslipidemia at risk of cardiovascular events.

  • StAR2D

    SMS supporting treatment for people with type 2 diabetes

  • TASMINH4

    Telemonitoring and/or self-monitoring of blood pressure in hypertension

  • SUMMIT-D

    Support through mobile messaging and digital health technology for diabetes

  • V-TEC

    An observational study to determine the incidence of venous thromboembolism among care home residents

  • HOME-BP

    Home and online management and evaluation of blood pressure

  • OPTiMISE

    OPtimising Treatment for MIld Systolic hypertension in the Elderly

  • OptimiseHFpEF

    Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care

  • OxRen

    Oxford renal longitudinal cohort study

In set-up

UDIP

OXREN II

OPTIMIZE HF

TASMINH5

Infections & acute care

  • ALIC4E

    Antivirals for influenza like illness? An RCT of clinical and cost effectiveness in primary care

  • ARCHIE

    The early use of antibiotics for ‘at risk’ children with influenza

  • ATAFUTI

    Alternative treatments of adult female urinary tract infection: a double blind, placebo controlled, factorial randomised trial

  • CONDUCT

    Can urine collection devices reduce the chances of contamination?

  • CRP pilot

    A pilot study on the effects of adding c-reactive protein (CRP) point-of-care testing in the management of acutely ill children in primary care

  • HEAT

    Helicobacter eradication to prevent ulcer bleeding in aspirin users trial

  • INVICTUS

    A world-first study to test a combination vaccine for influenza.

  • MERMAIDS

    Acute respiratory infections in adults

  • PACE

    Point of care testing to target antibiotics for chronic obstructive pulmonary disease exacerbations

  • PRINCESS

    Probiotics to reduce infections in care home residents, the PRINCESS trial

In set-up

ALABAMA

D-Mannose

Health behaviours & other conditions

  • HABIT

    Health professional Administered Brief Insomnia Therapy (HABIT) trial. A pragmatic, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy for insomnia disorder to sleep hygiene in primary care.

  • MaSC

    Brief interventions to support the management of smoking in primary care: a randomised controlled trial

  • TARS

    The aim of the study is to investigate whether Health Trainer support is better at helping people to quit smoking for longer, compared with existing support.

In set-up

PANDA-S

Stream

OWLET

DIAMOnD