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Completed studies from the Primary Care Clinical Trials Unit at the University of Oxford.

Automated Risk Assessment for Stroke in Atrial Fibrillation: A cluster randomised controlled trial of an electronic reminder intervention to promote anticoagulation and reduce stroke risk (AURAS-AF).

Study protocol 
Trial registration

An open randomised study of autoinflation in 4-11 year old school children with otitis media with effusion (OME) in primary care.


Effect of nasal balloon autoinflation in children with otitis media with effusion in primary care: an open randomized controlled trial.
Williamson I, Vennik J, Harnden A, Voysey M, Perera R, Kelly S, Yao G, Raftery J, Mant D, Little P.
CMAJ July 27 10.1503/cmaj.141608 

NIHR Signal

Epidemiology of Bordetella pertussis and Mycoplasma pneumoniae in children and adolescents presenting with acute persistent cough in primary care.

An exploratory study to assess feasibility and measure the impact of online health information, (experiential and fact-based) for self-management of asthma, motivation to stop smoking, and preparedness for caring for someone with multiple sclerosis.


Montelukast for young people and adults with persistent cough. A double blind randomised placebo controlled trial to help determine whether montelukast, a medication already used for the treatment of asthma and allergic rhinitis, is also effective at treating non-specific persistent coughs.

Trials Register


Montelukast for postinfectious cough in adults: a double-blind randomised placebo-controlled trial. 
Wang K, Taylor K, Jin J, Perera R, Farmer A, Mant D, Harden A, Birring SS, Fry NK, Harrison TG, Hay AD, Moore M, Little P.
The Lancet Respiratory Medicine 2013.  10.1016/S2213-2600(13)7024

This study examined how people respond to different medications based on their individual physiology to answer questions for the future study of varied treatment responses in type 2 diabetes.

Trial registry


Taking less oral glucose lowering treatment than prescribed is associated with a reduced improvement in 12 month HbA1c: a retrospective MASTERMIND cohort analysis stratified by type of treatment.
Farmer AJ, Shields BM, Lonergan M, Weedon M, Rodgers L, Donnelly LA, Holman RR, Pearson ER, Hattersley AT, Consortium MASTERMIND.
Diabetes Care 2016 10.2337/dc15-1194

What is the clinical and cost effectiveness of oral steroids in the treatment of acute lower respiratory tract infection? A placebo controlled randomised trial.

Trial registry

Treatment Options without Antibiotics for Sore Throat. A multi-centre, double blind, randomized, placebo-controlled trial to investigate whether corticosteroids given without antibiotics can ease the symptoms of a sore throat, and whether they are cost effective.

Trials registry

A pilot trial of corticosteroid injection for shoulder pain in primary care.


Corticosteroid injection for shoulder pain: single-blind randomized pilot trial in primary care.

Holt TA, Mant D, Carr A, Gwilym S, Beard D, Toms C, Yu LM, Rees J.

Trials. 2013 Dec 10;14:425.

This preliminary evaluation and feasibility study aimed to establish which parameters need to be part of a point of care testing consultation and informed the design of a larger clinical study.

This study aimed to determine the efficacy of a mHealth application, used within a community respiratory nurse service, with patients with moderate to severe COPD, in improving quality of life measured with the St Georges Respiratory questionnaire for COPD patients (SGRQ-C) in comparison with usual care