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Two licensed vaccines are available to prevent RVGE in infants. A worldwide critical review of economic evaluations of these vaccines was conducted. The objective was to describe differences in methodologies, assumptions and inputs and determine the key factors driving differences in conclusions. 68 economic evaluations were reviewed. RV vaccination was found to be cost-effective in developing countries, while conclusions varied between studies in developed countries. Many studies found that vaccination was likely to be cost-effective under some scenarios, such as lower prices scenarios, inclusion of herd protection, and/or adoption of a societal perspective. Other reasons for variability included uncertainty around healthcare visits incidence and lack of consensus on quality of life (QoL) valuation for infants and caregivers. New evidence on the vaccination effectiveness in real-world, new ways of modeling herd protection and assessments of QoL in children could help more precisely define the conditions under which RV vaccination would be cost-effective in developed countries.

Original publication

DOI

10.4161/hv.24253

Type

Journal article

Journal

Human Vaccines & Immunotherapeutics

Publication Date

2013

Volume

9

Pages

1272 - 1288

Keywords

rotavirus vaccination review economic evaluations cost-effectiveness pediatrics economic model potential cost-effectiveness national immunization program developing-countries diarrheal disease rix4414 rotarix(tm) young-children universal vaccination acute gastroenteritis routine immunization developed-countries