Protocol: A systematic review and network meta-analysis of the effects of different doses of licensed statins on LDL cholesterol in humans in order to generate dose-response curves
STEVENS R., Aronson JK., Monaghan G.
This is a protocol for a study in qhich we shall seek to generate dose-response curves relating the daily doses of different statins currently licensed for clinical use to their effects in reducing LDL cholesterol, for comparison of calculated ED50 values with the dosages typically used in clinical practice. This will also allow a comparison of the different dosages of different statins that are capable of producing the same LDL-lowering effect.