Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Plasma lipids are important risk factors for cardiovascular disease. Both genetic factors and diet are known to regulate lipid levels, and there has been a longstanding interest in how genes may interact with diet to modulate changes in lipid levels. Genome-wide association studies have recently identified the genes most strongly associated with variation in lipids within a population. In this paper, the current knowledge on gene-diet interactions to regulate lipid levels is discussed in light of these studies. Future genome-wide studies are required that specifically identify genes that are important modulators of lipid levels in response to dietary change. Some methodologic challenges inherent in these studies are discussed. © 2012 Springer Science+Business Media, LLC.

Original publication




Journal article


Current Nutrition Reports

Publication Date





123 - 131