Gene-Diet Interactions on Lipid Levels: Current Knowledge in the Era of Genome-Wide Association Studies
Walker CG., Jebb SA.
Plasma lipids are important risk factors for cardiovascular disease. Both genetic factors and diet are known to regulate lipid levels, and there has been a longstanding interest in how genes may interact with diet to modulate changes in lipid levels. Genome-wide association studies have recently identified the genes most strongly associated with variation in lipids within a population. In this paper, the current knowledge on gene-diet interactions to regulate lipid levels is discussed in light of these studies. Future genome-wide studies are required that specifically identify genes that are important modulators of lipid levels in response to dietary change. Some methodologic challenges inherent in these studies are discussed. © 2012 Springer Science+Business Media, LLC.