Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

The modern randomised controlled trial is the most reliable inferential means of investigating treatment effects. Its development during the 20th century turned clinical medicine into a rigorous experimental science. The second in a series, this article discusses the practical challenges of conducting trials including randomisation, allocation concealment and blinding, and explains concepts such as intention to treat and equipoise. Large diabetes randomised controlled trials are used as examples.


Journal article


Diabetes and Primary Care

Publication Date





82 - 87