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The discovery of insulin was among the most important medical advances of the 20th century, and led to rapid adoption into clinical practice. Since then, a substantial evidence base has developed to support both clinical care and self-management of diabetes through modern pharmaceutical and health services research. Research methods have also developed over the same timescale, enabling the detection of more subtle benefits, and of adverse effects only evident over longer intervals. The last in a series about evidence-based medicine, this article identifies the key principles underlying the primary care management of diabetes and reviews some of the evidence that supports them.


Journal article


Diabetes and Primary Care

Publication Date





346 - 357