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CLINICAL QUESTION: Among the 3 first-line smoking cessation treatments (nicotine replacement therapy [NRT], bupropion, and varenicline), which is most effective in helping people who smoke achieve and maintain abstinence from smoking for at least 6 months, and what serious adverse events are associated with each? BOTTOM LINE: Higher rates of smoking cessation were associated with NRT (17.6%) and bupropion (19.1%) compared with placebo (10.6%). Varenicline (27.6%) and combination NRT (31.5%) (eg, patch plus inhaler) were most effective for achieving smoking cessation. None of the therapies was associated with an increased rate of serious adverse events. Copyright 2014 American Medical Association. All rights reserved.

Original publication

DOI

10.1001/jama.2013.283787

Type

Journal article

Journal

JAMA - Journal of the American Medical Association

Publication Date

22/01/2014

Volume

311

Pages

193 - 194