© 2016 Elsevier B.V. This review of antihelminthic drugs published in the literature between January 2015 and December 2015 on includes albendazole, levamisole, oxantel pamoate and praziquantel. Dose comparison studies involving the use of albendazole, oxantel pamoate or praziquantel in antihelminthic therapy are reported. The first case of autoimmune hepatitis secondary to albendazole therapy is described, and bone dysplasia is also reported. Hemolytic anemia with hepatotoxicity and renal failure resulting from intravenous administration of albendazole in a child is also described. Bone marrow suppression and vasculitis attributed to suspected levamisole abuse are described. The abuse of levamisole-contaminated cocaine continues to be a common presentation in emergency care, and a special review is again included in this volume. Several cases of hematologic and immunologic symptoms and signs attributed to abuse of levamisole-contaminated cocaine are reported. Acute pancreatitis with resulting renal failure is described, and a fatal case due to thrombotic vasculopathy is reported. Varied presentations of immune complex glomerulonephritis caused by abuse of levamisole-contaminated cocaine are also reported. Cases of immune vasculitis with or without skin involvement are described. The results of a hospital-based case–control study exploring the association between praziquantel therapy and the risk of cholangiocarcinoma are reported.