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Subject: HIV-STI Title: Survival, causes of death, and risk factors associated with mortality in Barcelona HIV new diagnoses. 2001-2013 Presenting author: C.G. Authors: César Garrigaa,b, Patricia García de Olallaa,c, Roser Clos, a Pilar Gorrindoa, Macarena Garrido-Estepab and Joan A. Caylàa,c Affiliations: a(Public Health Agency of Barcelona, Spain )), b(Field Epidemiology Training Program, National Center for Epidemiology, Carlos III Health Institute, Spain), c(Biomedical Research Centres Network Consortium, Spain). Abstract background, methods, results and conclusions: Background The antiretroviral treatment has supposed a decrease in HIV-related mortality. We assessed factors related to survival in HIV individuals. Causes of death (CoD) in HIV individuals were described Methods Deaths registered in the Census until 30.06.2013 and 2001-2012 new diagnoses from Barcelona HIV Register were included in the analysis. The CoD were obtained from Death Register. The CoD were classified in external (ICD-10: X), HIV-related (B20-B24, B44.9, C83.7 and C85.9) and non-HIV-related (other codes) causes. Mortality rate was calculated as follow-up person-year per 1000 and its 95% confidence interval (M; 95%CI). Association with mortality of socio-demographic, clinical and epidemiological variables were studied using Cox regression [hazard ratio (HR); 95%CI] Results Among 3533 new HIV diagnoses, 168 (5%) died (M:8.2; 95%CI: 6.9-9.4). CoD was available in 93 (55%). Among those, 43% died by non-HIV-related causes (M:1.9; 95%CI:1.3-2.5); 42% by HIV-related causes (M:1.9; 95%CI:1.3-2.5), and 15% by external ones (M:0.7; 95%CI:0.3-1.0). Worse survival was observed in injecting drug users (IDU) (HR:4.7; 95%CI:2.9-7.7) and heterosexual (HTS) men (HR:2.4; 95%CI:1.4-3.9), Spaniards (HR:2.5; 95%CI:1.6-4.0), Gràcia district residents (HR:2.0; 95%CI:1.1-3.7), illiterate/primary education individuals (HR:1.5; IC95%:1.1-2.2), and <200 CD4 subjects (HR:1.8; 95%CI:1.2-3.0). HIV-related CoD were due to infections (48%): most common in men who have sex with men (MSM) (63%), followed by HTS women (60%). Non-HIV-related CoD were cancer (29%): more prevalent in men (32%), people with have secondary/university studies (39%) and HTS men (50%); cardiovascular diseases (22%): in HTS women (57%) and illiterate/primary education (35%) and; liver diseases (19%): in IDU (37%) Conclusions Mortality was associated with being IDU, HTS man, Spaniard, with low educational level and damaged immune system. CoD frequencies in HIV-related and non-HIV-related were similar Keywords: HIV Infections; Viral/epidemiology; Cause of Death; Follow-Up Studies; Registries Contact details: Ph.D., M.Sc., Biol.D., FETP, César Garriga, National Center for Epidemiology, Carlos III Health Institute, Pabellón 12. Avda. Monforte de Lemos, 5. 28029 Madrid. e-mails: • César Garriga: • Patricia García de Olalla: • Roser Clos: • Pilar Gorrindo: • Macarena Garrido-Estepa: • Joan A. Caylà:


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