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In this in vivo study, the skin reactivity of rabbits to Mineral Trioxide Aggregate (MTA) and Calcium Enriched Mixture (CEM) was compared. Sixteen albino rabbits were used. The dorsal skin in three areas (2x2 cm) of the rabbits was shaved 24 h prior to the test. The areas were randomly covered with freshly mixed biomatenals [MTA (n = 16), CEM (n = 16) andnormal saline (control, n = 16)], sterile gauze and bandages were placed for 4 hand the biomaterials were washed. The surface areas of the reactive skin sectiom were examined by naked eye and measured in 1,24,48 and 72 husing the Cavalier techmque. The animals were then sacrificed and hstological sections were prepared for blind examination. Results of macroscopic examination revealed a significant dfference (p = 0.003) between the average erythematous surface areas induced by MTA (1.61+0.32) and CEM (0.5+0.16). Results of histological examination showed that the hghest inflammation was obsenred in MTA, followed by CEM and control groups. Compkson of the difference in inflammatory cell count between each group revealed statistically significant dfferences in all cases (p<0.001). The results demomtrated that the biocompatibility of CEM cement is higher than MTA; CEM can be considered as a suitable endodontic biomaterial. © 2012 Asian Network for Scientific Information.

Original publication




Journal article


Pakistan Journal of Biological Sciences

Publication Date





250 - 254