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The EPICE and SHIPS studies constitute and follow up an area-based cohort of children born between 22+0 weeks and 31+6 weeks of gestation in 2011/2012 in all maternity units in 19 regions across 11 European countries. This study is using data from the EPICE and SHIPS studies to estimate economic costs and health-related quality of life outcomes during the fifth year of life associated with very preterm birth, and to explore which of a number of clinical and socioeconomic factors are associated with elevated costs or poor health-related quality of life outcomes.