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We are dedicated to the practice, teaching and dissemination of high-quality evidence-based medicine to improve healthcare in everyday clinical practice.
Evaluating potential treatments for COVID-19 infection in older people.
ARCHIE is a double-blind randomised placebo-controlled trial conducted in primary and secondary care settings which aims to determine whether giving the antibiotic co-amoxiclav to ‘at risk’ children within 5 days of them becoming ill with flu or influenza-like illness might: 1. Help stop them from developing bacterial infections and becoming more unwell. 2. Help them get better more quickly. 3. Affect how well antibiotics work against similar infections in future.
CONDUCT: The effectiveness and acceptability of two urine collection devices that aim to reduce contaminated urine samples in women presenting with symptoms of urinary tract infection
This trial will compare how many of the urine samples have been contaminated in each of the three groups using different methods. This study will also find out if the devices are cost-effective and how acceptable they are to patients and GPs.
EXPECT-1: Pilot Study to Assess Success Factors and Barriers for Preparation of a Phase 3 Study with ExPEC10V in Adults Aged 60 Years or Older and in Stable Health
This study is being carried out by researchers at general practices and hospitals worldwide to collect more information to support the development of a vaccine to prevent serious E-coli infections.
EXPECT-2: Prospective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli
Prospective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli (ExPEC) Isolated from Hospitalized Patients Aged 60 Years or Older with Invasive ExPEC Disease (IED) and to Evaluate the Clinical Case Definition.
This study aims to develop and test a better approach to assessing the likely cause (diagnosis) and future outcome (prognosis) of shoulder problems (pain).
Penicillin allergy status and its effect on antimicrobial prescribing, patient outcomes, and antimicrobial resistance.
Community acquired acute respiratory tract infection (CA-ARTI) in community care in Europe: point prevalence audit study (PPAS) of presentation and management.