Benefits and harms of statins in the UK population: doses versus effects
Applications will close at 12:00 midday on Friday 10th January 2020.
- DPhil in Primary Health Care
- Course information
Potential graduate research projects 2020/2021
- Important information
- Oxford-Wolfson-Marriott and Applied Research Collaboration (ARC) studentship in behavioural research and childhood obesity
- Developing the evidence for active intervention to support smoking cessation in cardiovascular disease (BHF funded studentship)
- Hypertension self-management in pregnancy
- Prevalence, safety and efficacy of deprescribing cardio-protective medications in older adults
- How people with long-term health conditions use digital health technologies
- Faith-based smoking cessation
- Improving smoking cessation training for undergraduates in UK medical schools
- Investigating socioeconomic inequalities in smoking cessation
- Developing and testing peer-led interventions to promote switching from smoking to vaping
- Obesity and non-alcoholic fatty liver disease
- Interventions to encourage healthier food purchasing
- Organisation and delivery of primary care
- A realist evaluation of implementing better care practices and bundled technologies in Kenyan Hospitals
- Feasibility of “fitness age” as a motivator for positive physical activity behaviour and improved health outcomes in UK primary care
- Progressing the role and evidence-base for ‘Exercise as Medicine’ in UK primary care settings
- Benefits and harms of statins in the UK population: doses versus effects
- Digital access: shaping the future of primary health care
- Workload in Primary Care and quality of care
- The epidemiology of UTI and antibiotic resistant uropathogens
- Evaluating temporal patterns in diagnostic meta-analysis
- Health economic aspects of childhood obesity
- Insomnia in menopause
- A framework for developing and implementing early phase economic modelling for diagnostic interventions
- Current DPhil projects
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- DPhil training programme
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How to apply: FAQs
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Statins, such as simvastatin and atorvastatin, are cholesterol-lowering drugs proven to reduce the risk of heart disease, but they also have known adverse effects, such as muscle pain, rarely leading to muscle damage, and an increased risk of diabetes mellitus.
Both the benefits and harms of any medication depend on the dose, and the relation between dose and effect is typically described by an equation called the Hill equation. However, there is little information on the relation between the doses of different statins and their beneficial or harmful effects.
This doctoral proposal aims to understand the relation between the doses of statins, their benefits, and their adverse effects (harms) by:
- systematically searching the literature for studies comparing different doses of a wide range of different statins;
- using the data to generate dose-response curves using network meta-analysis;
- estimating the parameters of the Hill equation for benefits and harms of statins, allowing comparisons between the different statins;
- analysing large databases of routine healthcare data from the UK. Looking for evidence of benefits and harms;
- combining the dose-response data with the clinical data to assess the risks of adverse outcomes in the general population.
Together, these results will shed light on the appropriateness of different doses of statins, and help inform the trade-off between benefit and harm.