Supervisor for Helen Ashdown: Predicting inhaled steroid responsiveness using near-patient testing: Personalizing long-term management of COPD in primary care. NIHR Clinical Research Training Fellowship, University of Oxford.
Supervisor for Haroon Ahmed: Improving Outcomes for Older People with Urinary Tract Infection in Primary Care. NIHR Clinical Research Training Fellowship, Cardiff University.
Co-supervisor for Elftheria Vasileiou: Seasonal Influenza Vaccine Effectiveness in Asthma. Asthma UK Centre for Applied Research, Edinburgh University.
Co-supervisor for Oghenekome Gbinigie: Improving the diagnosis and management of serious bacterial infections in older adults. Wellcome Trust, University of Oxford.
Co-supervisor for Rachel Greer: Can Testing for C-reactive Protein Improve the targeting of Antibiotics in the Community? Mahidol Oxford Tropical Medicine Research Unit, Open University.
Supervisor for Helene-Mari van der Westhuizen: Translating policy into practice: reducing nosocomial Tuberculosis transmission in South Africa. Rhodes Scholarship, University of Oxford.
Supervisor for Jienchi Dorward: Point-of-care viral load testing and mHealth adherence support to enhance primary care HIV services in South Africa. Wellcome Trust, University of Oxford.
BA MBChB DCH CCH MD FRCGP (Hon)FFPH FMedSci
Professor of Primary Care
- NIHR Senior Investigator
- Fellow of the Academy of Medical Sciences
- Professorial Fellow, Trinity College
- Director, Primary Care and Vaccines Clinical Trials Collaboration
- Director, NIHR Community Healthcare MedTech and In Vitro Diagnostics Co-operative
Chris Butler is Professor of Primary Care in the Nuffield Department of Primary Care Health Sciences, Professorial Fellow at Trinity College, and is the Clinical Director of the University of Oxford Primary Care Clinical Trials Unit. Chris is also the Director of the NIHR MedTech and In Vitro Diagnostics Cooperative for innovative diagnostic and monitoring technology to enhance Community Healthcare. He is a Fellow of the Academy of Medical Sciences and a National Institute for Health Research (NIHR) Senior Investigator, and practices as a salaried GP in Mountain Ash in South Wales for the Cwm Taf University Health Board.
Chris trained in Medicine at the University of Cape Town, did doctoral work at the University of Wales College of Medicine, and studied Clinical Epidemiology at The University of Toronto. He has led or helped lead > 20 randomised clinical trials, 13 qualitative studies, 10 prospective cohort studies, 6 systematic reviews and four large data studies. He has helped win >£140M in research and research infrastructure funding, and has >300 publications. He has supervised 12 out of 12 doctoral students to successful completion and currently has 5 doctoral students.
His main research interests are in common infections (especially the appropriate use of antibiotics and antibiotic resistance), and health behaviour change (especially adaptations of motivational interviewing in health care). His roles include:
Chief or Co-Chief investigator for the following current trials:
1. General Practitioner (GP) use of a C-Reactive Protein (CRP) Point of Care Test (POCT) to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit (The PACE Study). NIHR HTA. This study has recruited to target (>650 patients with acute exacerbations of COPD from > 70 GP practices), and the main study paper is in submission.
2. Antivirals for influenza Like Illness? An rCt of Clinical and Cost effectiveness in primary CarE (ALIC4E), which is part of the Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE) consortium. EU FP7. 3268 participants randomised in 16 countries; in analysis.
3. Probiotics to Reduce Infections iN Care homE reSidentS (PRINCESS). MRC Efficacy and Mechanisms Evaluation Board. Recruited to target: in follow up.
4. A phase II study to determine the safety and efficacy of candidate INfluenza Vaccine MVA-NP+M1 in combination with licensed InaCTivated inflUenza vaccine in adultS aged 65 years and above - INVICTUS. Funded by Vaccitech. In analysis.
Co-investigator on these current studies:
1. The effectiveness and acceptability of urine collection devices to reduce contaminated urine samples in women presenting with symptoms of urinary tract infection. A three arm trial in UK primary care (CONDUCT). NIHR RfPB. (CI Haywood)
2. Improving the uptake and SusTainability of Effective interventions to promote Prudent antibiotic Use in Primary care (STEP-UP). ESRC (Cross Council Initiative) (CI Walker)
3. A Multi-Centre Randomised Controlled Trial of Admission Avoidance Hospital at Home with Comprehensive Geriatric Assessment. NIHR SDO. (CI Shepherd)
4. Strengthening South Africa's health system through integrating treatment for mental illness into chronic disease care (Project MIND). Wellcome Trust-DIFFID. (CI Myers)
5. At-Risk Registers Integrated into primary care to Stop Asthma crises in the UK (ARRISA-UK): A pragmatic cluster randomised trial with nested economic and process evaluations examining the effects of integrating at-risk asthma registers into primary care with internet-based training and support. HTA. (CI Wilson)
6. Antibiotics for Lower Respiratory Tract Infections in Children presenting in Primary Care. NIHR HTA. (CI Little)
7. Antibiotic Reduction and Conservation in Hospitals (ARK-Hospital). NIHR RfPB Program Grant. (CI Peto)
8. Penicillin allergy status and its effect on antimicrobial prescribing, patient outcomes, and antimicrobial resistance. Short title: ALABAMA: Allergy AntiBiotics And Microbial resistance. NIHR Program Grant for Applied Research. (CI Sandoe)
9. D-mannose to prevent recurrent urinary tract infection (UTI): a double-blind, randomised, placebo controlled trial. NIHR SPCR (CI Hayward).
10. REspiratory Syncytial virus Consortium in EUrope (RESCEU). IMI 2 JU Funding
CI of platform grant:
NIHR MedTech and In Vitro Diagnostics Cooperative for innovative diagnostic and monitoring technology to enhance Community Healthcare
Co-Investigator on the following current platform grants:
1. Asthma UK Centre for Applied Asthma Research
2. NIHR Health Protection Research Unit on Health Care Associated Infections and Antimicrobial Resistance
National Institute for Health Research Senior Investigator (2016-2021)
Fellow of the Academy of Medical Sciences (2016-2021)
Clinical Director, Primary Care and Vaccines Clinical Trial Cooperative
Clinical Director, NIHR MedTech and In Vitro Diagnostics Cooperative for innovative diagnostic and monitoring technology to enhance Community Healthcare (2018-2023)
Salaried General Practitioner, Cwm Taf Health Board
Professorial Fellow, Trinity College, University of Oxford (since 2014).
Part time Professor, Department of Family Medicine, McMaster University (2002-ongoing)
Honorary Visiting Professor, Cardiff University (2016-ongoing)
Honorary Professor in the Department of Medicine, Division of Infectious Diseases and HIV Medicine at University of Cape Town (2017-ongoing)
Jury Member, Longitude Prize (2014-ongoing)
Butler CC. et al, (2013), BMJ (Online), 346
Francis NA. et al, (2018), The Lancet, 392, 557 - 568
Understanding the culture of prescribing: Qualitative study of general practitioners' and patients' perceptions of antibiotics for sore throats
(1998), British Medical Journal, 317, 637 - 642
Nuttall J. et al, (2009), BMJ (Online), 338
Butler CC. et al, (2019), New England Journal of Medicine, 381, 111 - 120
van Hecke O. et al, (2019), Br J Gen Pract
What the public think about participation in medical research during an influenza pandemic – an international cross-sectional survey
GOBAT N. et al, (2019), Public Health
Butler CC. et al, (2019), New England Journal of Medicine, 381, 111 - 120
Brookes-Howell L. et al, (2019), BJGP Open, 3
West RM. et al, (2019), J Antimicrob Chemother, 74, 2075 - 2082