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Johanna Cook

Senior Trial Manager and Team Lead (Infectious Diseases Research)

I am a Senior Trial Manager and Team Lead within the Primary Care Clinical Trials Unit (PC-CTU) with a specialty in infectious diseases research. The infectious diseases team in the  PC-CTU, is part of the Infectious Diseases Research Group within the Nuffield Department of Primary Care Health Sciences. Within this I manage a portfolio of infectious diseases trials. These range in topic from; influenza-like illness to UTIs to preventative probiotic treatments. This group is working on cutting edge research and running world leading clinical trials in the area of infectious diseases, with the aim of reducing our reliance and misuse of antibiotics.

One of the flagship studies in our portfolio, that I have set up, managed and now oversee, is an FP7 funded trial looking at response to flu across Europe with Prof Chris Butler called ALIC4E (Antivirals for influenza-Like Illness? an rCt of Clinical and Cost effectiveness in primary CarE). This trial is looking at the clinical and cost effectiveness of current flu treatments, new point of care tests to detect influenza and at the response to new strains of flu and is running on over 20 networks across Europe.

I started in the department as Trial Manager for TOAST (Treatment Options without Antibiotics for Sore Throat) a multi-centre, double blind, randomised, placebo-controlled trial looking at the treatment of sore throat with a single dose of an oral steroid in adults in primary care. TOAST is now part of the Infectious Diseases Research Group portfolio, and has recently been published in JAMA.

In addition to this my personal area of interest is in the efficient running of clinical trials and increasing the knowledge and expertise in this area. As such I am currently studying for am MSc in Evidence Based Health Care with my dissertation focusing on the payment of incentives to participants in trials. I also helped to set up and continue to teach an MSc module on Clinical Trial Management and have published a discussion piece on our current understanding and use of internal and external pilot trials.