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Research Summary

DPhil Supervision

Information coming soon

Chris Butler

Professor of Primary Care


Chris Butler is Professor of Primary Care at the Nuffield Department of Primary Care Health Sciences at the University of Oxford.  His main research interests are in common infections (especially the appropriate use of antimicrobials and antimicrobial resistance), and health behaviour change (especially motivational interviewing in health care).

He trained in Medicine at the University of Cape Town, did doctoral work at the University of Wales College of Medicine, and studied Clinical Epidemiology at The University of Toronto.

As CI or co-CI, he has just completed the National Institute of Health Research Health Technology Assessment  (NIHR HTA) funded Probiotics for Antibiotic Associated Diarrhoea (including Clostridium difficile) in Care homes (The PAAD Study), and the Diagnosis of Urinary Tract infection in Young children (DUTY) study.

His currently funded clinical trials include:

  1. The NIHR HTA funded Oral STeroids for Resolution of otitis media with effusion in CHildren: The OSTRICH Study (co-CI).
  2. The European Union Funding Program 6 (EU FP6) funded Point of Care Testing for Urinary Tract Infection in Primary Care (POETIC) study which is part of the Resistance in Gram-Negative Organisms: Studying Intervention Strategies (R-GNOSIS) consortium.
  3. The NIHR HTA funded ChildRen with Eczema, Antibiotic Management study (CREAM) study.
  4. The NIHR HTA funded General Practitioner (GP) use of a C-Reactive Protein (CRP) Point of Care Test (POCT) to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit (The PACE Study) (in set up).
  5. The EU FP7 funded Antivirals for influenza Like Illness? An rCt of Clinical and Cost effectiveness in primary CarE (ALIC4E), which is part of the Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE) consortium. 
  6. Probiotics to Reduce Infections iN Care homE reSidentS (PRINCESS), a trial funded by the EME Programme, an MRC and NIHR partnership.

Chris has led a Workpackage on three EU funded grants. He led the development of the clinical platform in 13 countries for the EU FP6 funded Genomics to Combat Resistance Against Antibiotics in Community Acquired Lower Respiratory Tract Infection (GRACE) Network of Excellence; in the FP6 EU funded Changing behaviour of Health care professionals And the general public towards a More Prudent use of anti-microbial agents (CHAMP); and in R-Gnosis. He also holds grants form the EU IMI and NIHR i4i programs.

He is a co-applicant on the Centre for the Development and Evaluation of Complex Interventions for Public Health Improvement(DECIPHer) –UKCRC Public Health Research Centre of Excellence and the Centre for the Improvement of Population Health through E-health Research (CIPHER) platform, both of which are funded by consortia that includes the Wellcome Trust. He is a co-applicant on the Asthma UK Centre for Applied Asthma Research program grant.

Chris is the Clinical Director of the University of Oxford Primary Care Clinical Trials Unit. He serves on; the Medical Research Council Efficacy and Mechanisms Board, the Jury for the Longitude Prize, the National Institute of Health Antimicrobial Resistance Reference Group, and the joint Academy of Medical Science/Wellcome Trust Steering Group on the Treatment of Epidemic Influenza.

He is an inaugural NISCHR Senior Faculty member, and holds an honorary Professorship at McMaster University. Chris is a recipient of the Royal College of General Practitioners John Fry award for “a younger member of the College who has promoted the discipline of general practice through research and publishing as a practising GP.”

His papers have twice been shortlisted for the BMJ Research Paper of the Year, and he has published over 195 indexed papers including 17 empirical studies in the British Journal of General Practice, 13 in the British Medical Journal, and 4 in The Lancet/Lancet Infectious Diseases. He has won over £100M in research and research infrastructure funding.

Chris practices as a general medical practitioner in, Mountain Ash, in South Wales.

Key Publications


Recent Publications

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