HepB-boost: Implementation of free-of-charge health care worker hepatitis B testing and vaccination at Kilifi County Referral Hospital, Kenya

Objectives Health care workers (HCWs) are at high risk of hepatitis B virus (HBV) exposure due to contact with blood and bodily fluids. In Kenya, HCWs are rarely fully vaccinated against HBV. During 2024, Kilifi County Referral Hospital (KCRH) in Kenya implemented HCW HBV testing and vaccination. We assess this implementation, including acceptability, feasibility, and costs. Methods A technical working group was formed at KCRH, sensitization was undertaken, and vaccines procured in multi-dose vials. Clinics were run for 2 hours twice weekly over 6 months. Hepatitis B surface antigen testing was available, and vaccination was offered at 0, 1, and 6 months. Results A total of 366 of 574 (64%) of staff received at least one vaccine. Of those attending, the number of fully vaccinated staff increased from 189 of 366 (5%) to 164 of 366 (45%), with 289 of 366 (79%) receiving at least two vaccines. A total of 125 of 366 (35%) were tested for hepatitis B surface antigen and four of 125 (3%) tested positive. The overall cost of the vaccination program was estimated at $4176, with each fully vaccinated person costing $25.45. A lack of HBV monovalent vaccine in multi-dose vials limited vaccination completion. Conclusions HBV vaccination for HCWs was feasible and acceptable at KCRH and could be offered at other similar sized hospitals. Consistent access to HBV monovalent vaccine must be a priority for Kenya.