Contact information
PhD/Post-doctoral projects
I am developing a series of projects aiming to extend our understanding of how we can expand the possibility of type 2 diabetes remission to more people, including people who don't need to or want to lose a lot of weight (eg>8kg) or who have type 2 diabetes of more than 6 years' duration. I would be happy to hear from clinicians and allied health professionals including dietitians who are interested in developing a PhD in this area.
I also have continued collaborations in NAFLD and NASH and likewise would be interested in hearing from clinicians thinking of pursuing a PhD or post-doctoral work in this area.
Nicola Guess
RD MPH PhD
NIHR Advanced Fellow
Senior Research Fellow
I am an academic dietitian and researcher specialising in the dietary prevention and management of type 2 diabetes.
I am a leading a research project aiming to develop and test a high-protein diet for the management of type 2 diabetes. This project aims to fill the gap in care for people with type 2 diabetes who have had the condition for more than 6 years, and who have any BMI.
I have a particular interest in calorie-independent dietary approaches to T2D management and have led a number of controlled efficacy trials in protein and carbohydrate manipulation to investigate their effects on glucose. Furthermore, there is a large gap in our understanding of how nutrition affects the underlying pathophysiology of type 2 diabetes so I also collaborate with islet researchers to understand how amino acids, and other dietary components affect acute and chronic beta-cell function.
I also continue with applied work in type 2 diabetes including SHIFT-Diabetes, which is working towards more targeted T2D management programmes for night shift-workers, and MY GODDESS (Malaysian GestatiOnal Diabetes and prevention of DiabetES Study) which aims to develop a digital intervention for women with gestational diabetes.
Recent publications
Precision nutrition must consider cost-effectiveness to deliver benefits to patients.
Journal article
Guess N. et al, (2026), Nat Med
Developing powerful PPIE partnerships in the design of an inclusive weight management service: a case study from the NewDAWN programme
Journal article
Mitchell C. et al, (2025), Research Involvement and Engagement, 11
Big data and personalized nutrition: the key evidence gaps.
Journal article
Guess N., (2024), Nat Metab, 6, 1420 - 1422
Evaluating the efficacy and mechanisms of a ketogenic diet as adjunctive treatment for people with treatment-resistant depression: A protocol for a randomised controlled trial
Journal article
Gao M. et al, (2024), Journal of Psychiatric Research, 174, 230 - 236
Identifying Preferred Features of Weight Loss Programs for Adults With or at Risk of Type 2 Diabetes: A Discrete Choice Experiment With 3,960 Adults in the U.K.
Journal article
Buckell J. et al, (2024), Diabetes Care, 47, 739 - 746