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We lead multidisciplinary applied research and training to rethink the way health care is delivered in general practice and across the community.
Predictive factors for the diagnosis of coeliac disease in children and young people in primary care: A systematic review and meta-analysis
Background Coeliac Disease (CD) often has its onset in childhood and affects 1% of the population. This review aimed to identify important predictive factors for coeliac disease in children and young people which could help GPs decide when to offer testing. Methods We searched MEDLINE, Embase and Cochrane Library to April 2024. Included studies were observational or randomized trials reporting the risk of CD when exposed to predictive factor(s) in people ≤25 years of age. Genetic factors were excluded. Risk of Bias was assessed using the Newcastle-Ottawa Scale. Random effects meta-analysis was performed for factors reported in ≥5 studies to calculate pooled odds ratios (OR) or standardized mean differences (SMD). Results Of 11,623 unique abstracts, 183 were included reporting on 140+ potentially associated factors. Meta-analyses of 28 factors found 14 significant associations with CD diagnosis: having type 1 diabetes (OR 8.70), having a first degree relative with coeliac disease (OR 5.19), being of white ethnicity (OR 2.56), having thyroid disease (OR 2.16), being female (OR 1.53), more frequent gastroenteritis in early childhood (OR 1.48), having frequent respiratory infections in early childhood (OR 1.47), more gluten ingestion in early life (OR 1.25), having more infections in early life (OR 1.22), antibiotic use in early childhood (OR 1.21), being born in the summer (OR 1.09), breastfeeding (OR 0.79) older age at diagnosis of type 1 diabetes (OR 0.64), and heavier weight (SMD -0.21). The final three were associated with lower risk of CD diagnosis. Discussion This is the first systematic review and meta-analysis of predictive factors for CD in children. Amongst the 14 factors we identified that were significant, three were potentially modifiable: breast feeding, antibiotic use and amount of gluten ingestion in early childhood. This work could inform the development of clinical support tools to facilitate the early diagnosis of CD.
Health system readiness to deliver integrated noncommunicable disease and antenatal care in Kyrgyzstan, Tajikistan, and Vietnam
Introduction: Globally, noncommunicable diseases (NCDs) are a leading cause of death among women of reproductive age. Reproductive, maternal, newborn, and child health (RMNCH) services provide an important opportunity to prevent, detect, and manage NCDs. Yet, NCD and mental health care remain poorly integrated into RMNCH services in many settings. We aimed to explore the feasibility of integrating NCD and mental health interventions into RMNCH interventions in Kyrgyzstan, Tajikistan, and Vietnam. Materials and Methods: We conducted a secondary analysis of data from a WHO project on integrating NCD and mental health interventions into RMNCH services across three countries. Our analysis used the WHO health systems building blocks framework to structure inquiry and synthesis across key areas such as service delivery, workforce, and governance. Results: Maternal mortality remains high in all three countries and antenatal care is hospital oriented. We identified several common barriers at the primary care level, including inadequate knowledge of NCDs and mental health conditions among healthcare workers, a lack of essential equipment, and weak coordination among healthcare providers across levels of care. Integrated management is not routinely included in training programs and adherence to clinical guidelines remains low. Conclusions: The healthcare systems in all three countries are not well prepared to provide integrated care. Greater emphasis is needed on strengthening primary care to ensure high-quality integrated services. Alongside updating training programs and securing the availability of essential equipment and commodities, there is a need to update clinical protocols on integrated management and revise monitoring systems to support quality improvement. The global level needs to address the research gaps and provide more support to countries to prioritize integrated care.
Expectations and experiences of pain during medical abortion at home: A secondary, mixed-methods analysis of a patient survey in England and Wales
Objective: To explore experiences of pain during medical abortion and provide patient-centred recommendations for improving abortion experience and pain counselling. Methods: We invited patients of British Pregnancy Advisory Service who underwent medical abortion up to 10 weeks' gestation to participate in an online, English language questionnaire from November 2021 to March 2022. Participants answered questions about pain, method preference, abortion experience, advice, and how they would describe pain experienced to a friend. In this secondary analysis, we analysed free-Text responses using reflexive thematic analysis techniques. We used descriptive statistics and parametric tests to analyse quantitative responses. Results: Of 11 906 patients invited to participate, 1596 (13.4%) completed the questionnaire, including at least one free-Text comment. Participants used a range of descriptors for medical abortion pain across three broad themes: pain severity, pain quality and comparisons to other reproductive pain. Some found the commonly used analogy to period pain misleading. Many felt unprepared for the level of pain they experienced, which they attributed to provider comparisons to period pain, as well as a lack of detailed, realistic anticipatory pain counselling. Qualitative and quantitative results suggest pain experiences impact method preference. Participants recommended better counselling for pain and abortion preparation, including first-hand accounts of medical abortion at home and a wide and accessible range of descriptions of pain. Conclusions: Abortion providers should use patient-centred recommendations to better prepare patients for pain during medical abortion. Setting realistic expectations can improve abortion experience and support informed method choice. Further research is needed to develop and test patient-centred counselling materials.
The benefits and harms of oral iron supplementation in non-anaemic pregnant women: a systematic review and meta-analysis
Background: Iron deficiency during pregnancy poses a significant risk to both maternal and foetal health. Current international guidelines provide discrepant advice on antenatal iron supplementation for non-anaemic women. Objective: We aimed to quantify the benefits and harms of routine antenatal supplementation in non-anaemic women. Methods. The Cochrane Library, MEDLINE, Embase, and clinical trial registries were searched for randomized controlled trials and observational studies comparing oral iron supplementation with placebo or no supplement in non-anaemic pregnant women. Risk of bias was assessed for each study and the results were synthesized via meta-analysis. Results: Twenty-three eligible studies were identified with 4492 non-anaemic pregnant women. Supplemented groups had higher haemoglobin [mean difference = 6.95 g/l, 95% confidence interval (CI): 4.81–9.09, P
The Pandemic EVIDENCE Collaboration (EVidence-Informed DevelopmEnt of Non-PharmaCological IntErventions) Pillar 1 : Diagnostics and Transmission
Slide presentation Pillar 1 : Diagnostics and Transmission
Commentary: Without Values, Complexity is Reduced to Mathematics
This commentary on Sturmberg and Mercuri's paper ‘Every Problem is Embedded in a Greater Whole’ [1] argues that those authors have approached complexity from a largely mathematical perspective, drawing on the work of Sumpter. Whilst such an approach allows us to challenge the simple linear causality assumed in randomised controlled trials, it is itself limited. Mathematical complexity can explain nonlinearity and network effects but it cannot explain human values. It overlooks, for example, how science itself is historically and culturally shaped and how values-driven misunderstandings and conflicts are inevitable when people with different world views come together to try to solve a problem. This paper argues that the mathematical version of complexity thinking is necessary but not sufficient in medical research, and that we need to enhance such thinking further with attention to human values.
What caused the Covid-19 pandemic?
This chapter considers the COVID-19 pandemic as an example of a complex, emergent and global phenomenon, the numerous causes of which must be examined at multiple levels through different ontological and epistemological lenses. After providing examples of biomedical explanations which depict the pandemic somewhat reductively in terms of biomedical and molecular causes, we introduce the notion of performative causality-the pandemic begins when it is "declared". We explore how a particular version of the pandemic was brought into being through certain social actions, including "front-stage" presentations of particular versions of science and more informal, "back-stage" efforts to enrol and mobilize others to back a particular course of action. We describe how scientific enquiry during the pandemic was culturally and politically shaped using the example of the flawed "droplet narrative" explanation of SARS-CoV-2 transmission. Using Bourdieu's notions of habitus, field, orthodoxy and heterodoxy, we show how aerosol scientists who were less powerfully positioned were ignored and their explanations rejected by policymakers at the World Health Organization and (consequently) by national public health bodies. Finally, we consider how the awkward and contested ways in which the pandemic may end.
How to Read a Paper: The Basics of Evidence-Based Healthcare, Seventh Edition
Learn to assess published research in this best-selling introduction to evidence-based healthcare Evidence-based practices have revolutionized medical care. Clinical and scientific papers have something to offer practitioners at every level of the profession, from students to established clinicians in medicine, nursing and allied professions. Novices are often intimidated by the idea of reading and appraising the research literature. How to Read a Paper demystifies this process with a thorough, engaging introduction to how clinical research papers are constructed and how to evaluate them. Now fully updated to incorporate new areas of research, readers of the seventh edition of How to Read a Paper will also find: A careful balance between the principles of evidence-based healthcare and clinical practice New chapters covering consensus methods, mechanistic evidence, big data and artificial intelligence Detailed coverage of subjects like assessing methodological quality, systemic reviews and meta-analyses, qualitative research, and more. How to Read a Paper is ideal for all healthcare students and professionals seeking an accessible introduction to evidence-based healthcare – particularly those sitting undergraduate and postgraduate exams and preparing for interviews.
Differences in the effectiveness of individual-level smoking cessation interventions by socioeconomic status.
BACKGROUND: People from lower socioeconomic groups are more likely to smoke and less likely to succeed in achieving abstinence, making tobacco smoking a leading driver of health inequalities. Contextual factors affecting subpopulations may moderate the efficacy of individual-level smoking cessation interventions. It is not known whether any intervention performs differently across socioeconomically-diverse populations and contexts. OBJECTIVES: To assess whether the effects of individual-level smoking cessation interventions on combustible tobacco cigarette use differ by socioeconomic groups, and their potential impact on health equalities. SEARCH METHODS: We searched the Cochrane Database of Systematic Reviews from inception to 1 May 2023 for Cochrane reviews investigating individual-level smoking cessation interventions. We selected studies included in these reviews that met our criteria. We contacted study authors to identify further eligible studies. SELECTION CRITERIA: We included parallel, cluster or factorial randomised controlled trials (RCTs) investigating any individual-level smoking cessation intervention which encouraged complete cessation of combustible tobacco cigarette use compared to no intervention, placebo, or another intervention in adults. Studies must have assessed or reported smoking quit rates, split by any measure of socioeconomic status (SES) at longest follow-up (≥ six months), and been published in 2000 or later. DATA COLLECTION AND ANALYSIS: We followed standard Cochrane methods for screening, data extraction, and risk of bias assessment. We assessed the availability of smoking abstinence data by SES in lieu of selective reporting. The primary outcome was smoking cessation quit rates, split by lower and higher SES, at the longest follow-up (≥ six months). Where possible, we calculated ratios of odds ratios (ROR) with 95% confidence intervals (CIs) for each study, comparing lower to higher SES. We pooled RORs by intervention type in random-effects meta-analyses, using the generic inverse-variance method. We subgrouped by type of SES indicator and economic classification of the study country. We summarised all evidence in effect direction plots and categorised the intervention impact on health equality as: positive (evidence that the relative effect of the intervention on quit rates was greater in lower rather than higher SES groups), possibly positive, neutral, possibly neutral, possibly negative, negative, no reported statistically significant difference, or unclear. We evaluated certainty using GRADE. MAIN RESULTS: We included 77 studies (73 from high-income countries), representing 127,791 participants. We deemed 12 studies at low overall risk of bias, 13 at unclear risk, and the remaining 52 at high risk. Included studies investigated a range of pharmacological interventions, behavioural support, or combinations of these. Pharmacological interventions We found very low-certainty evidence for all the main pharmacological interventions compared to control. Evidence on cytisine (ROR 1.13, 95% CI 0.73 to 1.74; 1 study, 2472 participants) and nicotine electronic cigarettes (ROR 4.57, 95% CI 0.88 to 23.72; 1 study, 989 participants) compared to control indicated a greater relative effect of these interventions on quit rates in lower compared to higher SES groups, suggesting a possibly positive impact on health equality. CIs for both estimates included the possibility of no clinically important difference and of favouring higher SES groups. There was a lower relative effect of bupropion versus placebo on quit rates in lower compared to higher SES groups, indicating a possibly negative impact on health equality (ROR 0.05, 95% CI 0.00 to 1.00; from 1 of 2 studies, 354 participants; 1 study reported no difference); however, the CI included the possibility of no clinically important difference. We could not determine the intervention impact of combination or single-form nicotine replacement therapy on relative quit rates by SES. No studies on varenicline versus control were included. Behavioural interventions We found low-certainty evidence of lower quit rates in lower compared to higher SES groups for print-based self-help (ROR 0.85, 95% CI 0.52 to 1.38; 3 studies, 4440 participants) and text-messaging (ROR 0.76, 95% CI 0.47 to 1.23; from 3 of 4 studies, 5339 participants; 1 study reported no difference) versus control, indicating a possibly negative impact on health equality. CIs for both estimates included the possibility of no clinically important difference and of favouring lower SES groups. There was very low-certainty evidence of quit rates favouring higher SES groups for financial incentives compared to balanced intervention components. However, the CI included the possibility of no clinically important difference and of favouring lower SES groups (ROR 0.91, 95% CI 0.45 to 1.85; from 5 of 6 studies, 3018 participants; 1 study reported no difference). This indicates a possibly negative impact on health equality. There was very low-certainty evidence of no difference in quit rates by SES for face-to-face counselling compared to less intensive counselling, balanced components, or usual care. However, the CI included the possibility of favouring lower and higher SES groups (ROR 1.26, 95% CI 0.18 to 8.93; from 1 of 6 studies, 294 participants; 5 studies reported no difference), indicating a possibly neutral impact. We found very low-certainty evidence of a greater relative effect of telephone counselling (ROR 4.31, 95% CI 1.28 to 14.51; from 1 of 7 studies, 903 participants; 5 studies reported no difference, 1 unclear) and internet interventions (ROR 1.49, 95% CI 0.99 to 2.25; from 1 of 5 studies, 4613 participants; 4 studies reported no difference) versus control on quit rates in lower versus higher SES groups, suggesting a possibly positive impact on health equality. The CI for the internet intervention estimate included the possibility of no difference. Although the CI for the telephone counselling estimate only favoured lower SES groups, most studies narratively reported no clear evidence of interaction effects. AUTHORS' CONCLUSIONS: Currently, there is no clear evidence to support the use of differential individual-level smoking cessation interventions for people from lower or higher SES groups, or that any one intervention would have an effect on health inequalities. This conclusion may change as further data become available. Many studies did not report sufficient data to be included in a meta-analysis, despite having tested the association of interest. Further RCTs should collect, analyse, and report quit rates by measures of SES, to inform intervention development and ensure recommended interventions do not exacerbate but help reduce health inequalities caused by smoking.
A realist evaluation to explain and understand the role of paramedics in primary care.
BACKGROUND: In response to the unsustainable workload and workforce crises in primary care, paramedics (with their generalist clinical background acquired from ambulance service experience) are increasingly employed in primary care. However, the specific contribution paramedics can offer to the primary care workforce has not been distinctly outlined. We used realist approaches to understand the ways in which paramedics impact (or not) the primary care workforce. METHODS: A realist evaluation was undertaken, consisting of three independent but inter-related research studies: In WP1, a mixed-methods cross-sectional survey of paramedics in primary care in the UK was conducted to comprehend the existing practices of paramedics within the NHS. WP2 involved an analytic auto-netnography, where online conversations among paramedics in primary care were observed to understand paramedics' perceptions of their role. WP3 utilised focused observations and interviews to delve into the impact of paramedics on the primary care workforce. This comparative study collected data from sixty participants across fifteen sites in the UK, and twelve participants across three sites in a specific region in Canada, where Community Paramedicine is well established. RESULTS: The culmination of findings from each phase led to the development of a final programme theory, comprising of 50 context-mechanism-outcome configurations (CMOCs) encompassing three conceptual categories: Expectations associated with paramedics in primary care, the transition of paramedics into primary care roles, and the roles and responsibilities of paramedics in primary care. CONCLUSIONS: Our realist evaluation used a mixed-method approach to present empirical evidence of the role of paramedics in primary care. It offers insights into factors relating to their deployment, employment, and how they fit within the wider primary care team. Based on the evidence generated, we produced a series of practice implementation recommendations and highlighted areas for further research.
Admission to acute medical wards for mental health concerns among children and young people in England from 2012 to 2022: a cohort study
Background: There are challenges in providing high quality care for children and young people who are admitted to acute medical wards for mental health concerns. Although there is concern that these admissions are increasing, national data describing these patterns are scarce. We aimed to describe trends in these admissions in England over a 10-year period, and to identify factors associated with repeat admission and length of stay. Methods: In this cohort study we used data on all admissions to medical wards in England among children and young people aged 5–18 years from April 1, 2012, to March 31, 2022. We classified admissions for mental health concerns using the Global Burden of Disease Study cause hierarchy. We described national trends in admissions for mental health concerns over time by sex, age, ethnicity, and index of multiple deprivation quintile. We examined associations between sociodemographic and clinical factors and odds of the admission lasting more than 1 week, as well as hazard ratios of repeat admissions, using mixed-effects models. Findings: We identified 342 511 admissions for any cause in children and young people aged 5–18 years in 2021–22 in England, of which 39 925 (11·7%) were for mental health concerns. 21 337 (53·4%) admissions for mental health concerns were due to self-harm. Between 2012–13 and 2021–22, annual admissions for mental health concerns increased from 24 198 to 39 925 (65·0% increase), whereas all-cause admissions increased from 311 067 to 342 511 (10·1% increase). Increases were particularly steep in females aged 11–15 years, rising from 9091 to 19 349 (112·8% increase), and for eating disorders, rising from 478 to 2938 (514·6% increase). In 2021–22, 3130 (7·8%) admissions for mental health concerns lasted longer than 1 week, compared with 12 044 (3·5%) all-cause admissions. Of 239 541 children and young people who were admitted for mental health concerns between 2012–13 and 2021–22, 32 107 (13·4%) had a repeat admission within 6 months. The odds of long-stay admission and hazard ratios for being readmitted were significantly higher for children and young people aged 11–15 years, those who were female, those from less deprived areas, and those with eating disorders than among other groups. Interpretation: We found large increases in the number of children and young people admitted to acute medical wards for mental health concerns over a 10-year period. Further work is needed to understand factors driving these trends and how to improve care for children and young people with mental health concerns admitted to medical wards. Funding: National Institute for Health and Care Research