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A blog by Dr Gurpreet Singh Kalra and Shawn D. Mathis, members of cohort 1 of the MSc in Global Healthcare Leadership
British Society of Gastroenterology national evaluation of colonoscopy quality: findings from the National Endoscopy Database.
BACKGROUND AND AIMS: The aim of this study was to analyze national colonoscopy quality with the use of automatically uploaded data from a national database, including exploring performance variation. METHODS: Data on all colonoscopies performed in the United Kingdom from March 1, 2019, to Februa…
Physical, cognitive, and social triggers of symptom fluctuations in people living with long COVID: an intensive longitudinal cohort study
Background: Symptom fluctuations within and between individuals with long COVID are widely reported, but the extent to which severity varies following different types of activity and levels of exertion, and the timing of symptoms and recovery, have not previously been quantified. We aimed to characterise t…
Interventions for quitting vaping.
ObjectivesThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: To conduct a living systematic review to assess the benefits and harms of interventions to help people quit vaping compared to each other or to placebo or no intervention. We will also assess how these interventions…
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitag…
Echocardiography reporting in heart failure with preserved ejection fraction: Delphi consensus study.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome in which signs and symptoms of heart failure (HF) occur despite a normal left ventricular ejection fraction. Transthoracic echocardiography (TTE) is the first-line imaging modality but disparities in patient pathways…
Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (Icterus oberi)
Polyglucosan bodies are accumulations of insoluble glucose polymers and proteins that form intracytoplasmic inclusions in the brain, large numbers of which can be indicative of neurodegenerative diseases such as Lafora disease. Montserrat orioles (Icterus oberi) are an icterid passerine endemic to Montserrat w…
An international comparison of longitudinal health data collected on long COVID in nine high income countries: a qualitative data analysis
Background: Long coronavirus disease (COVID) presents a significant health challenge. Long-term monitoring is critical to support understanding of the condition, service planning and evaluation. We sought to identify and examine longitudinal health data collected on long COVID to inform potential decisions…
Creating a Modified Version of the Cambridge Multimorbidity Score to Predict Mortality in People Older Than 16 Years: Model Development and Validation
Background: No single multimorbidity measure is validated for use in NHS (National Health Service) England’s General Practice Extraction Service Data for Pandemic Planning and Research (GDPPR), the nationwide primary care data set created for COVID-19 pandemic research. The Cambridge Multimorbidity…
Pornography Use Among Adults in Britain: A Qualitative Study of Patterns of Use, Motivations, and Stigma Management Strategies.
Pornography use is common but stigmatized. In this study, we present a qualitative analysis of the patterns of, and motivations for, using pornography and how the stigma of using pornography manifests in participants' accounts. We draw on Meisenbach's (2010) theory of stigma management communication (…
Models of Diabetes Care Across Different Resource Settings
All countries, regardless of the gross domestic product, face challenges in providing quality healthcare for people with diabetes and other non-communicable diseases (NCDs). Hence many may struggle to achieve a one-third reduction in premature mortality from NCDs, including diabetes, by 2030 through preven…
Monitoring Diabetes
Optimizing management of diabetes includes monitoring of glucose levels. Raised glucose levels are associated with increased levels of complications. Timely introduction and adjustment of therapy is required to maintain glucose levels in a range where the risks of complications are minimized. The tests used for…
A viro-immunological model to characterize the antiviral effect of molnupiravir in SARS-CoV-2-infected outpatients: implication for treatment duration.
BACKGROUND: The antiviral efficacy of molnupiravir against SARS-CoV-2 is controversial. Here, we develop a model integrating viral and immune dynamics to characterize the mechanism of action of molnupiravir in vivo and its impact on viral dynamics, during and after treatment. METHODS: We analysed data…
Saline nasal irrigation for acute sinusitis (SNIFS II): a randomised controlled pilot trial with nested process evaluation.
BACKGROUND: Despite having marginal beneficial effects, antibiotics are routinely prescribed in adults with acute sinusitis. Alternative interventions for this common condition are urgently needed. AIM: To assess the feasibility and acceptability of saline nasal irrigation for acute sinusitis. DESIGN & SETTING: Rand…
Exploring health and social care preferences for people with dementia and mild cognitive impairment: a systematic review of discrete choice experiments
Objectives: Dementia is associated with behaviour change, and impaired ability to remember and think. This review focuses on key findings and methodological processes from discrete choice experiments (DCEs) to inform health and social care interventions for people living with dementia or mild co…
The relationship between attachment and mental health at work: A narrative review.
BackgroundWell-being at work is a critical concern, with a significant portion of the workforce reporting adverse mental health impacts due to work-related stress.ObjectiveThis narrative review explores the relationship between attachment theory and work-related mental health, focusing on how attachment inf…
Better engagement, better evidence: working in partnership with patients, the public, and communities in clinical trials with involvement and good participatory practice
In May 2022, member states of WHO adopted the World Health Assembly WHA75.8 resolution on strengthening clinical trials to provide high-quality evidence on health interventions and to improve research quality and coordination. The resolution recognises the central role of community stakeholders in the clinic…