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Dr Oliver van Hecke and Professor Chris Butler argue that antibiotic resistance applies to us all.
Clinical Trials Day 20 May 2022 - “We couldn’t do it without you.”
Clinical trials
17 May 2022
Clinical Trials Day gives us an opportunity to reflect on, and appreciate, recent achievements and the people who have made these achievements possible. So, this year we want to say a big thank you to everyone involved, “we couldn’t do it without you”.
The PRINCIPLE Trial - two years on
COVID-19 Clinical trials
16 May 2022
The PRINCIPLE Trial has led the way in evaluating treatments for COVID-19 in the community over the last two years.
Self-monitoring of blood pressure does not result in the earlier detection of high blood pressure in pregnancy nor does it improve blood pressure control in those with pregnancy hypertension
Clinical trials Patient experience
3 May 2022
Self-monitoring of blood pressure during pregnancy neither results in earlier detection of high blood pressure, nor helps with blood pressure control in those who are pregnant, suggest the results of two new papers based on research from the University of Oxford and King’s College London (funded by the National Institute of Health and Care Research).
Primary care research nurses nominated for OUH Award
Awards & appointments COVID-19 Clinical trials
13 April 2022
Congratulations to the amazing team of research nurses working in the Primary Care Clinical Trials Unit who have been shortlisted as finalists in the Oxford University Hospitals NHS Foundation Trust Staff Recognition Awards 2021.
10,000 people join the PRINCIPLE Trial – A huge ‘Thank You’ from us all.
COVID-19 Clinical trials
4 April 2022
10,000 people have joined the PRINCIPLE Trial over the last two years and we want to say a big ‘Thank You’ to them all for their amazing contribution to testing treatments for COVID-19 in the community.
PANORAMIC hits the 20,000 participant milestone
COVID-19 Clinical trials
31 March 2022
The world’s largest study of community-based treatments for acute COVID-19 has reached a world-first, historic milestone: over twenty thousand participants from across the UK have now taken part in the PANORAMIC trial.
Recruitment begins for national community COVID-19 antiviral trial
COVID-19 Clinical trials Public engagement & involvement
8 December 2021
Researchers from the University of Oxford have today started recruiting participants for a first-of-its-kind clinical trial to test novel antiviral COVID-19 treatments for use early on in the illness by people in the community with COVID-19 and those who are at higher risk of complications – partnering with the National Institute for Health Research (NIHR) and working with colleagues in several UK universities, and the NHS UK-wide.
PRINCIPLE trial 'highly commended' for innovative use of health data
Big data COVID-19 Clinical trials
5 July 2021
The PRINCIPLE trial has been highly commended at the Health Data Research UK Awards for the way in which patient data is utilised so participants are contacted about the trial soon after receiving a positive test result.
Ivermectin to be investigated as a possible treatment for COVID-19 in the PRINCIPLE trial
COVID-19 Clinical trials Infection & acute care
23 June 2021
From today, ivermectin is being investigated in the UK as part of the Platform Randomised Trial of Treatments in the Community for Epidemic and Pandemic Illnesses (PRINCIPLE), the world’s largest clinical trial of possible COVID-19 treatments for recovery at home and in other non-hospital settings.
Celebrating International Clinical Trials Day 2021
COVID-19 Clinical trials
20 May 2021
Each year, International Clinical Trials Day recognises the people who conduct clinical trials, giving our community a chance to say thank you for everything they do to improve public health. This year our trials unit staff are sharing what makes them proud to be part of Oxford’s Primary Care Clinical Trials Unit.
Asthma drug budesonide shortens recovery time in non-hospitalised patients with COVID-19
COVID-19 Clinical trials Infection & acute care
12 April 2021
Inhaled budesonide, a common corticosteroid, is the world's first widely available, inexpensive drug found to shorten recovery times in COVID-19 patients aged over 50 who are treated at home and in other community settings, reports the PRINCIPLE trial in 1,779 participants. As of today, the treatment is available in UK primary care on a case-by-case basis.
Favipiravir to be investigated as a possible COVID-19 treatment for at-home recovery in the PRINCIPLE trial
COVID-19 Clinical trials Infection & acute care
8 April 2021
Could the antiviral favipiravir help transform COVID-19 into an illness that can be successfully treated by general practitioners?
PRINCIPLE Covid-19 treatments trial widens to under 50s and adds colchicine
COVID-19 Clinical trials Infection & acute care
3 March 2021
From today, the UK’s national priority platform trial of Covid-19 treatments for recovery at home launches its investigation of the gout drug colchicine, and expands for the first time to include adults of any age.
Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial
Big data COVID-19 Clinical trials Infection & acute care
25 January 2021
Update from the Chief Investigators of the Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE), 25 January 2021
Inhaled corticosteroids to be investigated as a possible treatment for Covid-19 in national PRINCIPLE Trial
COVID-19 Clinical trials Infection & acute care
27 November 2020
In Covid-19, inhaled budesonide may prevent damaging inflammation, stop the virus from getting into lung cells and inhibit viral replication.
Two major pharmacy chains join PRINCIPLE Trial
COVID-19 Clinical trials
18 November 2020
Two of the UK’s largest pharmacy chains, LloydsPharmacy and Well Pharmacy, are tasking their branches with helping to find suitable patients for the PRINCIPLE Trial of Covid-19 treatments.
RCGP Research Paper of the Year awarded to study led by Professor Chris Butler
Awards & appointments Clinical trials Infection & acute care
23 October 2020
The importance of patient and public contributors is recognised as key to the success of the study.
Britain’s most influential Hindu temple spreads awareness of the PRINCIPLE trial among Indian community
COVID-19 Clinical trials Infection & acute care
21 October 2020
Europe’s BAPS Swaminarayan Sanstha, the largest Hindu temple outside of India, is supporting their community during the coronavirus pandemic by spreading awareness of the PRINCIPLE trial of Covid-19 treatments.
PRINCIPLE Trial of COVID-19 treatments recruits 1000th participant
COVID-19 Clinical trials Infection & acute care
1 October 2020
More than 1000 people across the UK have signed-up to take part in the UK-wide PRINCIPLE Trial of potential community-based treatments for COVID-19, led by Oxford University.
PRINCIPLE Trial to strengthen Black, Asian and minority ethnic community participation
COVID-19 Clinical trials
18 September 2020
Professor Mahendra G Patel, University of Bradford, joins PRINCIPLE Trial as National Black, Asian and minority ethnic Community and Pharmacy Lead