It’s false to believe that antibiotic resistance is only a problem in hospitals – GP surgeries are seeing it too — Nuffield Department of Primary Care Health Sciences, University of Oxford

Clinical Trials Day 20 May 2022 - “We couldn’t do it without you.”

17 May 2022

Clinical Trials Day gives us an opportunity to reflect on, and appreciate, recent achievements and the people who have made these achievements possible. So, this year we want to say a big thank you to everyone involved, “we couldn’t do it without you”.

The PRINCIPLE Trial - two years on

16 May 2022

The PRINCIPLE Trial has led the way in evaluating treatments for COVID-19 in the community over the last two years.

Self-monitoring of blood pressure does not result in the earlier detection of high blood pressure in pregnancy nor does it improve blood pressure control in those with pregnancy hypertension

3 May 2022

Self-monitoring of blood pressure during pregnancy neither results in earlier detection of high blood pressure, nor helps with blood pressure control in those who are pregnant, suggest the results of two new papers based on research from the University of Oxford and King’s College London (funded by the National Institute of Health and Care Research).

Primary care research nurses nominated for OUH Award

13 April 2022

Congratulations to the amazing team of research nurses working in the Primary Care Clinical Trials Unit who have been shortlisted as finalists in the Oxford University Hospitals NHS Foundation Trust Staff Recognition Awards 2021.

10,000 people join the PRINCIPLE Trial – A huge ‘Thank You’ from us all.

4 April 2022

10,000 people have joined the PRINCIPLE Trial over the last two years and we want to say a big ‘Thank You’ to them all for their amazing contribution to testing treatments for COVID-19 in the community.

PANORAMIC hits the 20,000 participant milestone

31 March 2022

The world’s largest study of community-based treatments for acute COVID-19 has reached a world-first, historic milestone: over twenty thousand participants from across the UK have now taken part in the PANORAMIC trial.

Recruitment begins for national community COVID-19 antiviral trial

8 December 2021

Researchers from the University of Oxford have today started recruiting participants for a first-of-its-kind clinical trial to test novel antiviral COVID-19 treatments for use early on in the illness by people in the community with COVID-19 and those who are at higher risk of complications – partnering with the National Institute for Health Research (NIHR) and working with colleagues in several UK universities, and the NHS UK-wide.

PRINCIPLE trial 'highly commended' for innovative use of health data

5 July 2021

The PRINCIPLE trial has been highly commended at the Health Data Research UK Awards for the way in which patient data is utilised so participants are contacted about the trial soon after receiving a positive test result.

Ivermectin to be investigated as a possible treatment for COVID-19 in the PRINCIPLE trial

23 June 2021

From today, ivermectin is being investigated in the UK as part of the Platform Randomised Trial of Treatments in the Community for Epidemic and Pandemic Illnesses (PRINCIPLE), the world’s largest clinical trial of possible COVID-19 treatments for recovery at home and in other non-hospital settings.

Celebrating International Clinical Trials Day 2021

20 May 2021

Each year, International Clinical Trials Day recognises the people who conduct clinical trials, giving our community a chance to say thank you for everything they do to improve public health. This year our trials unit staff are sharing what makes them proud to be part of Oxford’s Primary Care Clinical Trials Unit.

Asthma drug budesonide shortens recovery time in non-hospitalised patients with COVID-19

12 April 2021

Inhaled budesonide, a common corticosteroid, is the world's first widely available, inexpensive drug found to shorten recovery times in COVID-19 patients aged over 50 who are treated at home and in other community settings, reports the PRINCIPLE trial in 1,779 participants. As of today, the treatment is available in UK primary care on a case-by-case basis.

Favipiravir to be investigated as a possible COVID-19 treatment for at-home recovery in the PRINCIPLE trial

8 April 2021

Could the antiviral favipiravir help transform COVID-19 into an illness that can be successfully treated by general practitioners?

PRINCIPLE Covid-19 treatments trial widens to under 50s and adds colchicine

3 March 2021

From today, the UK’s national priority platform trial of Covid-19 treatments for recovery at home launches its investigation of the gout drug colchicine, and expands for the first time to include adults of any age.

Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial

25 January 2021

Update from the Chief Investigators of the Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE), 25 January 2021

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