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Deciding which patients will benefit from antibiotics is not always easy. (Image of a clipboard with antibiotics written on in capital letters) © Shutterstock

Making medical research work where it matters most: Global team calls for revolution in GP and community health and care trials

An international team, led the Nuffield Department of Primary Care Health Sciences, is calling for a fundamental shift in how we conduct health research to better serve our real-world health and care needs.

Antiviral molnupiravir offers only modest longer-term benefits for COVID-19, finds new paper from the PANORAMIC trial

Can the long-term consequences of COVID 19 be reduced through the use of novel antiviral medicines? New research from the PANORAMIC trial, run in NDPCHS Clinical Trial Unit and funded and delivered by the NIHR, has found that treating vaccinated, higher-risk adults with COVID-19 with the antiviral drug molnupiravir offers only modest benefits when it comes to reducing long term effects of the acute illness.

PRINCIPLE and PANORAMIC teams honoured with prestigious Prix Galien Award

The teams behind the PRINCIPLE and PANORAMIC clinical trials, run in the Clinical Trials Unit at the Nuffield Department of Primary Care Health Sciences, have been awarded the prestigious Prix Galien Best Public Sector Innovation Award 2024 for their work in conducting innovative, large-scale clinical trials during the COVID-19 pandemic.

Ground-breaking art exhibition, The PANORAMIC PRINCIPLE, unveiled at Celebratory Symposium

The PANORAMIC PRINCIPLE art exhibition, by CTU artist-in-residence Tanya Poole, was unveiled at the PRINCIPLE-PANORAMIC Celebratory Symposium this week. The portraits interpret the human experience of conducting and participating in the trials and honour the diverse array of participants, researchers, and medical professionals whose inclusive efforts set global benchmarks and transformed lives.

Celebrating innovation: the PRINCIPLE-PANORAMIC Celebratory Symposium

Researchers, clinicians, supporters and PPI contributors gathered on Monday to celebrate the innovative PRINCIPLE and PANORAMIC clinical trials that evaluated potential treatments for COVID-19 during the pandemic and broke recruitment records for community-based trials in doing so. Both trials were run by the Clinical Trails Unit (CTU) in NDPCHS.

Celebrating collaboration and resilience: The PRINCIPLE PANORAMIC art exhibition

Celebrate the resilience and collaboration behind Oxford's groundbreaking PANORAMIC and PRINCIPLE COVID-19 trials through "The PANORAMIC PRINCIPLE" exhibition. Artist Tanya Poole's powerful portraits honour the diverse array of participants, researchers, and medical professionals whose inclusive efforts set global benchmarks and transformed lives. An inspiring tribute to human determination in the face of adversity.

New study shows ivermectin lacks meaningful benefits in COVID-19 treatment

New research led by the University of Oxford has concluded that the antiparasitic drug ivermectin does not provide clinically meaningful benefits for treating COVID-19 in a largely vaccinated population.

PANORAMIC trial finds molnupiravir may not be a cost-effective treatment for COVID-19 in at-risk adults

A new evaluation from the University of Oxford’s ongoing PANORAMIC trial suggests that an antiviral treatment, called molnupiravir, used to treat COVID-19 may not be cost-effective at its current price of £513 per course, compared to usual NHS care and support, in the first six months after infection. However, it may be beneficial for patients over the age of 75.

Nuffield Department of Primary Care Health Sciences set to deliver clinical trials expertise to China National Biotec Group in new collaboration

The training initiative builds the foundations to explore further collaborations encompassing joint research efforts, leadership programmes, and a shared commitment to advancing clinical trials.

New Oxford Study Shows Brief Sleep Therapy Delivered by Nurses Improves Insomnia

Researchers from the University of Oxford have found that a brief form of cognitive behavioural therapy (CBT) for insomnia, delivered by nurses in GP surgeries, significantly improves sleep and quality of life compared to sleep hygiene alone.

Rapid weight loss found to be safe and helpful for people with liver disease, Oxford trial reveals

A clinical trial, led by a team at NDPCHS, has shown that a three-month rapid weight loss programme was not only safe but also effective in reducing the severity of a liver disease called non-alcoholic steatohepatitis (NASH) with liver fibrosis.

Multi-cancer blood test showed ‘real promise’ in NHS trial

An NHS trial of a new blood test for more than 50 types of cancer, led by the University of Oxford, correctly revealed two out of every three cancers among over 5,000 people who had visited their GP with suspected symptoms, in England or Wales. The test also correctly identified the original site of cancer in 85% of those cases.

Introducing Proxemis: the University of Oxford and EMIS have announced a new joint venture, Proxemis, an end-to-end clinical trial solution

Combining the world-renowned expertise of the Nuffield Department of Primary Care Health Science's Clinical Trials Unit with the software and data management capabilities of EMIS, Proxemis is reimagining research to support healthier lives with a uniquely tailored experience for clinical trial delivery.

Professor Chris Butler addresses the UN on PANORAMIC - BAPS UK & Europe collaboration

Recently, Professor Chris Butler addressed the United Nations regarding the PANORAMIC Trial and the assistance of BAPS UK & Europe.

PANORAMIC trial finds molnupiravir does not reduce COVID-19 hospitalisation/deaths in vaccinated people at high risk

Researchers from the University of Oxford have today released findings from a clinical trial investigating the effectiveness of the antiviral treatment molnupiravir against COVID-19 – the first treatment tested in the ongoing PANORAMIC trial.

PANORAMIC and PRINCIPLE Pharmacy, and Diversity and Inclusivity Lead made an Officer of the Order of the British Empire (OBE)

PANORAMIC wins big at the Thames Valley Health Research Awards 2022

Clinical Trials Day 20 May 2022 - “We couldn’t do it without you.”

Clinical Trials Day gives us an opportunity to reflect on, and appreciate, recent achievements and the people who have made these achievements possible. So, this year we want to say a big thank you to everyone involved, “we couldn’t do it without you”.

The PRINCIPLE Trial - two years on

The PRINCIPLE Trial has led the way in evaluating treatments for COVID-19 in the community over the last two years.

Self-monitoring of blood pressure does not result in the earlier detection of high blood pressure in pregnancy nor does it improve blood pressure control in those with pregnancy hypertension

Self-monitoring of blood pressure during pregnancy neither results in earlier detection of high blood pressure, nor helps with blood pressure control in those who are pregnant, suggest the results of two new papers based on research from the University of Oxford and King’s College London (funded by the National Institute of Health and Care Research).

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