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<br/><strong>Background and aims: </strong>Little is known about the long-term economic consequences of smoking during pregnancy. We estimated the association between smoking in pregnancy and the costs of delivering health-care to infants and children in England, and investigated which aspects of care are the key drivers of these costs.<br/><strong>Methods: </strong>We used Hospital Episode Statistics (HES) linked with Clinical Practice Research Datalink (CPRD) data in England from January 2003 to January 2015 in children with longitudinal data for at least 1, 5 and 10 years after birth. Poisson regression provided rate ratios (RR) and 95% confidence intervals (CIs) comparing health-care episode rates between those exposed and not exposed to smoking during pregnancy. Linear regression was used to compare estimated costs between groups (pound sterling, 2015 prices) and generalized linear multivariable (GLM) models adjusted for potentially moderating factors.<br/><strong>Results: </strong>A total of 93152 singleton pregnancies with the required data were identified. Maternal smoking in pregnancy was associated with higher primary care, prescription and hospital in-patient episode rates, but lower out-patient visit and diagnostic test rates. Adjusting for year of birth, socio-economic deprivation, parity, sex of child and delivery method showed that maternal smoking in pregnancy was associated with increased child health-care costs at 1 year [average cost difference for children of smokers, beta = pound 91.18, 95% confidence interval (CI) = pound 47.52-134.83 and 5 years of age (beta = pound 221.80, 95% CI = pound 17.78-425.83], but not at 10 years of age (beta = pound 365.94, 95% CI = - pound 192.72 to pound 924.60).<br/><strong>Conclusion: </strong>In England, maternal smoking in pregnancy is associated with increased child health-care costs over the first 5 years of life; these costs are driven primarily by greater hospital in-patient care.

Original publication




Journal article





Publication Date





1305 - 1316