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Kinetic studies of L-arginine transport in human platelets have identified a high-affinity, low-capacity transport system [Michaelis-Menten constant (K(m)) about 10 μM] for cationic amino acids that also transports neutral amino acids with high affinity in the presence of Na + but not K + . These characteristics, together with our kinetic cis-inhibition studies, indicate that saturable L-arginine transport in human platelets is mediated via the system y + L and not the classic cationic transporter system y + . We present here the first evidence that L-arginine transport via system y + L is increased twofold in platelets from patients with chronic renal failure. System y + L has been described in human erythrocytes, peripheral blood mononuclear cells and placenta, and up-regulation of system y + L activity in human platelets could explain the paradox of increased nitric oxide (NO) production by uraemic platelets under conditions of decreased plasma L- arginine and elevated N(G)-monomethyl-L-arginine (L-NMMA) concentrations.

Original publication

DOI

10.1007/s004240051078

Type

Journal article

Journal

Pflugers Archiv European Journal of Physiology

Publication Date

15/09/1999

Volume

438

Pages

573 - 575