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OBJECTIVES: To measure secondary attack rates (SARs) in prospectively followed household contacts of paediatric and adult cases of SARS-CoV-2 infection in England. METHODS: Self-taken nasal swabs from household contacts of PCR confirmed cases of COVID-19 and blood samples on day 35 were tested for evidence of infection with SARS-CoV-2 virus. RESULTS: The secondary attack rate (SAR) among 431 contacts of 172 symptomatic index cases was 33% (95% confidence intervals [CI] 25-40) and was lower from primary cases without respiratory symptoms, 6% (CI 0-14) vs 37% (CI 29-45), p=0.030. The SAR from index cases <11 years was 25% (CI 12-38). SARs ranged from 16% (4-28) in contacts <11 years old to 36% (CI 28-45) in contacts aged 19-54 years (p=0.119). The proportion infected who developed symptoms (78%) was similar by age (p=0.44) though <19 year olds had fewer mean number of symptoms than adults (p=0.001) and fewer reported loss of sense of taste or smell (p=0.0001). CONCLUSIONS: There are high risks of transmission of SARS-CoV-2 virus in the home, including those where infection is introduced by a child. The risk of children acquiring infection was lower than that in adults and fewer developed typical symptoms of Covid-19 infection.

Original publication

DOI

10.1016/j.jinf.2021.07.037

Type

Journal article

Journal

J Infect

Publication Date

01/08/2021

Keywords

SARS-CoV-2 transmission, households, secondary attack rates by age