Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Background: People from British South Asian communities have an increased risk of mortality from coronary heart disease (CHD). Doxazosin, a selective α 1 -adrenergic blocker, in addition to lowering blood pressure, has been shown to have positive effects on glucose metabolism and lipid profiles in patients with hypertension. Aim: We studied doxazosin (1-8 mg) and bendrofluazide (2.5 mg) in patients of British South Asian origin with existing mild to moderate hypertension (doxazosin n = 78; bendrofluazide n = 82), to compare their effects on glucose and lipid metabolism in this group. Design of Study: A 34-week randomised, double-blind, parallel-group, multicentre study. Setting: Primary care in the UK. Method: All doxazosin patients started with an initial dose of 1 mg once daily, titrated to a maximum 8 mg once daily if diastolic blood pressure was > 90 mmHg or was not < 5 mmHg of the baseline value. The primary efficacy variables were mean glucose and total cholesterol concentrations at week 21. Result: Doxazosin reduced glucose, total cholesterol, low-density lipoprotein-cholesterol and triglycerides anal increased high-density lipoprotein-cholesterol. There were significant differences between doxazosin and bendrofluazide for glucose concentrations at week 21 (P = 0.029) and week 34 (P = 0.015), total cholesterol at week 21 (P = 0.048) and triglycerides at week 21 (P = 0.047) and week 34 (P = 0.009). There was no significant difference in blood pressure lowering between the two treatments. Conclusion: Doxazosin exhibits beneficial effects on glucose concentrations and lipid profile, in particular in lowering triglyceride concentrations in British South Asians. Whether these desirable characteristics translate to improved overall cardiovascular risk requires formal evaluation. © British Journal of General Practice 2005.

Type

Journal article

Journal

British Journal of General Practice

Publication Date

01/06/2005

Volume

55

Pages

437 - 443