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Combination therapy or concomitant drug administration can be associated with pharmacokinetic drug–drug interactions, increasing the risk of adverse drug events and reduced drug efficacy. Thus far, machine-learning models have been developed that can classify drug–drug interactions. However, to enable quantification of the pharmacokinetic effects of a drug–drug interaction, regression-based machine learning should be explored. Therefore, this study investigated the use of regression-based machine learning to predict changes in drug exposure caused by pharmacokinetic drug–drug interactions. Fold changes in exposure relative to substrate drug monotherapy were collected from 120 clinical drug–drug interaction studies extracted from the Washington Drug Interaction Database and SimCYP compound library files. Drug characteristics (features) were collected such as structure, physicochemical properties, in vitro pharmacokinetic properties, cytochrome P450 metabolic activity, and population characteristics. Three different regression-based supervised machine-learning models were then applied to the prediction task: random forest, elastic net, and support vector regressor. Model performance was evaluated using fivefold cross-validation. Strongest performance was observed with support vector regression, with 78% of predictions within twofold of the observed exposure changes. The results show that changes in drug exposure can be predicted with reasonable accuracy using regression-based machine-learning models trained on data available early in drug discovery. This has potential applications in enabling earlier drug–drug interaction risk assessment for new drug candidates.

Original publication

DOI

10.1002/psp4.12884

Type

Journal article

Journal

CPT: Pharmacometrics and Systems Pharmacology

Publication Date

01/01/2023

Volume

12

Pages

122 - 134