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The integrase strand transfer inhibitor, dolutegravir (DTG), is widely used in first- and second-line antiretroviral therapy (ART) regimens in South Africa. We describe an adult with virological failure on second-line tenofovir/lamivudine/dolutegravir (TLD2) and rapid emergence of DTG resistance within 3 months, while receiving rifapentine-based tuberculosis preventive therapy.

Original publication

DOI

10.4102/sajhivmed.v26i1.1701

Type

Journal article

Journal

Southern African Journal of HIV Medicine

Publisher

AOSIS

Publication Date

23/04/2025

Volume

26