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Patients with manic depressive disorder (DSM-III-R bipolar disorder) have an abnormality of the Na+,K(+)-ATPase pumps in their lymphocytes: the pump numbers do not upregulate to stimulation with lithium and ethacrynate. We have now investigated the in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase pumps in the first-degree unaffected relatives of patients with a clear history of manic depressive disorder. The lymphocytes of the healthy relatives upregulated their Na+,K(+)-ATPase pumps normally, suggesting that the abnormal response that we have previously observed in patients with the disorder reflects a complex relation between the biochemical phenotype and the development of clinical symptoms.

Type

Journal article

Journal

J Affect Disord

Publication Date

16/04/1995

Volume

34

Pages

33 - 39

Keywords

Bipolar Disorder, Cells, Cultured, Ethacrynic Acid, Humans, Lithium Chloride, Lymphocytes, Sodium-Potassium-Exchanging ATPase, Up-Regulation