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We have measured the effects of digoxin on the cation transport mechanisms of patients' erythrocytes during treatment with digoxin for atrial fibrillation and cardiac failure in sinus rhythm. The results show that during short-term treatment with digoxin there is occupation of erythrocytic cardiac glycoside receptors by digoxin with resultant inhibition of active cation transport. These effects correlate well with the patients' clinical responses to treatment. During long-term treatment, however, these effects are not seen, suggesting that there is pharmacological tolerance to the effects of digoxin. The clinical implications of these results are discussed. © 1981 Springer-Verlag.

Original publication

DOI

10.1007/BF01720552

Type

Journal article

Journal

Klinische Wochenschrift

Publication Date

01/12/1981

Volume

59

Pages

1323 - 1332