Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We have studied the effects of digoxin on cation transport in vivo by measuring the changes in plasma and red cell rubidium concentrations following an oral load of rubidium chloride. In eight patients who had been taking digoxin for 7 to 10 days (mean plasma digoxin concentration 1.3 ng ml‐1) the rise in plasma rubidium concentrations was enhanced and the rise in red cell rubidium concentrations was attenuated following the oral load of rubidium chloride, by comparison with the changes in well‐matched controls. In contrast, the disposition of rubidium was not altered in 12 patients who had been taking digoxin for more than 3 months (mean plasma digoxin concentration 1.1 ng ml‐1). These results suggest that the inhibitory effects of digoxin on cation transport are detectable in vivo during short‐term therapy, but not during long‐term therapy, and confirm our previous in vitro findings. 1986 The British Pharmacological Society

Original publication

DOI

10.1111/j.1365-2125.1986.tb02875.x

Type

Journal article

Journal

British Journal of Clinical Pharmacology

Publication Date

01/01/1986

Volume

22

Pages

27 - 30