HLA correlates in a cohort of slow progressors from china: Effects on HIV-1 disease progression
Rai MA., Zhang Y., Yindom L., Holmes J., Yu L-M., Hao C., Rostron T., Yan H., Zhang YL., Cai C., Mcmichael AJ., Dong2 T., Rowland-Jones SL., Blais M., Xu KY.
We looked at our HIV + Slow Progressors Cohort to determine if there were any HLA correlates for protection. No statistically significant allelic differences were found between the HIV + and control cohorts using regression analysis, though trends were noted. Data for Elite Controllers showed increased frequency of B*57. Likewise, no correlation was inferred with the clinical data of the HIV + cohort. We hypothesize that the protective effect of HLA alleles may have been lost over time.