Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Macrophages contribute to autoimmune diseases and inflammation through their ability to present autoantigens and through their potent effector mechanisms unleashed during innate and acquired cellular and humoral immunity. We describe macrophage receptors that recognize and respond to modified self and foreign ligands, mediating homeostatic clearance of dying cells and their products, as well as altered gene expression, secretion of cytocidal products and host defense against infection. A range of macrophage molecules have been implicated in controlling the balance between tolerance and excessive immune activation. Further studies with macrophage-restricted gene modification are needed to establish a primary role for macrophages in tissue-specific autoimmune diseases. © 2014 Elsevier Inc. All rights reserved.

Original publication

DOI

10.1016/B978-0-12-384929-8.00011-3

Type

Journal article

Publication Date

01/12/2013

Pages

161 - 174