Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

© 2017 American Association for Cancer Research. Background: Several investigations assessed the association of Vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other Vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the VDR, Vitamin D-binding protein (GC), 7-dehydrocholesterol reductase (DHCR7), Vitamin D 25- hydroxylase (CYP2R1), and Vitamin D 24-hydroxylase (CYP24A1) genes with total and site-specific cancer incidence endpoints. Results: Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03-1.39], although this was no longer significant after correcting for multiple testing. Conclusions: Our data provide little to no evidence of a major influence of Vitamin D genetic predisposition on cancer risks. Impact: Large-scale genetic epidemiology consortia and metaanalysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of Vitamin D with the risk of cancer.

Original publication




Journal article


Cancer Epidemiology Biomarkers and Prevention

Publication Date





1459 - 1461