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We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

Original publication

DOI

10.1038/ng1571

Type

Journal article

Journal

Nature Genetics

Publication Date

01/06/2005

Volume

37

Pages

590 - 592