pREVention and management tools for rEducing antibiotic Resistance in high prevalence SEttings (REVERSE)

The goal of REVERSE is to develop and implement cost-effective strategies and tools for the prevention and clinical management of healthcare-associated infections due to multidrug-resistant pathogens, and to reduce the burden of antimicrobial resistance in high-prevalence healthcare settings. REVERSE will answer questions about real-life effectiveness of infection prevention and control programmes in combination with antibiotic stewardship on healthcare-associated infections due to multidrug-resistant microorganisms. It will offer implementation strategies to the participating hospitals, as well as studying the cost-effectiveness of additional external implementation support in a hybrid implementation-effectiveness stepped wedge cluster randomised trial. REVERSE will incorporate effects of antimicrobial resistance into cost-effectiveness analyses, facilitated by direct measurement of the incidence of resistance infections, as well as potential impacts on colonisation. Nested within the trial is a cohort study evaluating the impact of antimicrobial resistant infections on quality of life. At the completion of the project, four European countries (Greece, Italy, Romania and Spain) will have a platform of highly experienced hospitals to build on, and expand a national network for combatting antibiotic resistance. For more details see: https://www.reverseproject.eu/