D-Mannose to prevent recurrent UTI: a double-blind randomised placebo controlled trial
Urinary tract infections (UTIs) are the most common bacterial infection seen in women presenting to UK primary care, accounting for up to 3% of all GP consultations. Approximately 40-50% of women experience at least one episode during their lives. D-mannose, which is a sugar, is currently available as a food supplement. Some women find it very helpful in reducing the number of UTIs they experience, but others don’t. Previous research suggests that using D-mannose can reduce the number of UTIs experienced by women who have frequent UTIs. We aim to recruit 508 women to take the supplement or a placebo for six months. Our results should then give us the confidence to advise women who suffer with recurrent UTIs whether D-mannose might be helpful to manage their condition.
This study aims:
- to assess the effectiveness of D-mannose in preventing symptomatic UTI,
- to determine whether daily use of D-mannose compared with placebo by women who experience RUTIs reduces the symptom burden of UTI,
- to determine whether daily use of D-mannose compared with placebo by women who experience RUTIs reduces antibiotic prescription for UTI.
A within trial economic evaluation will be conducted as part of this study.
Find out more:
Oxford project lead:
Colleagues from the Nuffield Department of Primary Care Health Sciences, University of Oxford
2017 – 2020
National Institute for Health Research School for Primary Care Research