Heart Failure Research
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Research has altered UK & European Guidelines on Heart Failure
Research into the main causes and impact of heart failure, with a linked programme on its better diagnosis.
This theme involves the follow up of a well phenotyped cohort and a number of heart failure diagnostic and management studies. The ECHOES programme represents one of the world’s largest study cohorts exploring heart failure (HF) and left ventricular systolic dysfunction (LVSD).
Echocardiographic Community Heart of England Screening trial (Davies MK, Hobbs FDR, Davis RC, Kenkre JE, Roalfe AK, Hare R, Wosornu D, Lancashire RJ). Prevalence of left ventricular systolic dysfunction and heart failure in the general population: main findings from the ECHOES (Echocardiographic Heart of England Screening) Study. Lancet 2001; 358: 439-445).
Linked sub-studies have reported on the reliability of natriuretic peptides (BNP and NT pro-BNP) as diagnostic and prognostic indicators of heart failure; quality of life in heart failure; mortality in all cause, all stage heart failure; and delivered data on the potential for screening for heart failure. Recent work including an HTA systematic review and IPD meta-analysis of heart failure diagnosis and a major re-phenotyping of the entire surviving ECHOES cohort.
Current work includes the REFER trial of natriuretic peptide measurement, compared to a clinical decision rule, or their combination, in heart failure diagnosis.