Brian D Nicholson
MRCGP BSc MSc (Health Res) DPhil
Associate Professor
- NHS General Practitioner
- NIHR EME Advanced Fellow
- NIHR Cancer Awareness Screening and Early Diagnosis Policy Research Unity - Co-Director
- Affiliate Investigator - KPWHRI
- Visiting Associate Professor - Lee Kong Chian School of Medicine - NTU Singapore
Contact information
+44 (0)1865 289300
Diagnosis and Cancer in Primary Care
Brian's academic interests include cancer, global health, and evidence-based diagnosis.
His research aims to improve the diagnostic process for patients with symptoms of cancer. This work focusses on understanding symptoms, appropriate test use, and developing clinical pathways.
He leads the departmental Cancer Theme that conducts research in four main areas: health records data; implementation science; diagnostic reasoning; and clinical trials and prospective studies. He is Early Detection lead for the CRUK Oxford Cancer Centre investigating community-based multi-cancer testing. He is a member of the NIHR EME Committee and the CRUK EDD Committee.
He supervises DPhil and MSc students, medical students, postdocs, Academic Clinical Fellows. He is a GP in Oxford City.
Colleges
Research groups
Key publications
manifesto for improving cancer detection: four key considerations when implementing innovations across the interface of primary and secondary care
Journal article
Dowrick A. et al, (2024), The Lancet Oncology, 25, e388 - e395
Evaluation of the diagnostic accuracy of two point-of-care tests for COVID-19 when used in symptomatic patients in community settings in the UK primary care COVID diagnostic accuracy platform trial (RAPTOR-C19)
Journal article
Nicholson BD. et al, (2023), PLoS ONE, 18
Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study
Journal article
Nicholson BD. et al, (2023), Lancet Oncology, 24, 733 - 743
Faecal immunochemical testing for adults with symptoms of colorectal cancer attending English primary care: a retrospective cohort study of 14 487 consecutive test requests
Journal article
Nicholson BD. et al, (2020), Alimentary Pharmacology and Therapeutics, 52, 1031 - 1041
Prioritising primary care patients with unexpected weight loss for cancer investigation: Diagnostic accuracy study
Journal article
Nicholson BD. et al, (2020), The BMJ, 370
Blood CEA levels for detecting recurrent colorectal cancer: A Diagnostic Test Accuracy Review.
Journal article
Nicholson BD. et al, (2015), Cochrane Database of Systematic Reviews
Recent publications
Supporting women with adherence to adjuvant endocrine therapy (SWEET): feasibility study of the HT&Me intervention
Journal article
McGeagh L. et al, (2026), European Journal of Oncology Nursing, 80
Outpatient hospital attendances in people with rheumatoid arthritis during the COVID-19 pandemic and beyond: a cohort study in three nations of the UK
Journal article
Costello RE. et al, (2026), Rheumatology, 65