Dimitrios Koutoukidis
RD PhD MSc AFHEA
Associate Professor
- NIHR Advanced Fellow
- NIHR Oxford BRC Senior Research Fellow
Diet, Obesity, and Behavioural Sciences
My research has generated rigorous evidence addressing long-standing uncertainty about the role of intentional weight loss in selected obesity-related disease areas. It has demonstrated that structured weight loss interventions can be safe, clinically effective and cost-effective. I have led multi-centre randomised controlled trials within the NHS evaluating low-energy total diet replacement programmes prior to cancer surgery. We have also examined weight regain following GLP-1 receptor agonist medication, highlighting the importance of integrating pharmacological and behavioural approaches to optimise long-term outcomes.
Prior to this, I established intentional weight loss as a clinically meaningful treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) through influential systematic reviews, translational collaborations and clinical trials. My research has informed international clinical guidelines. Across my programme, I bring together behavioural science, clinical trials and epidemiological research to address obesity as a modifiable driver of chronic disease risk.
Alongside research leadership, I am committed to developing research capacity and strengthening research culture. I supervise doctoral and pre-doctoral students, serve on the NIHR Health Services and Delivery Research funding panel, and contribute to public engagement activities.
Recent publications
-
An intensive weight loss programme with behavioural support for people with type 2 diabetes at risk of eating disorders in England (ARIADNE): a randomised, controlled, non-inferiority trial
Journal article
Tsompanaki E. et al, (2025), Lancet Psychiatry, 12, 483 - 492
-
Severe Dietary Energy Restriction for Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomised Controlled Trial
Journal article
Koutoukidis D. et al, (2025), Journal of Cachexia, Sarcopenia and Muscle, 16
-
The impact of weight loss interventions on disordered eating symptoms in people with overweight and obesity: a systematic review & meta-analysis
Journal article
Tsompanaki E. et al, (2025), eClinicalMedicine, 80
-
The societal implications of using glucagon-like peptide-1 receptor agonists for the treatment of obesity
Journal article
Scragg J. et al, (2025), Med
-
Optimising a digitally delivered behavioural weight loss programme: study protocol for a factorial cluster randomised controlled trial
Journal article
Wren GM. et al, (2024), Trials, 25