Contact information
+44 (0)1865 617192
https://orcid.org/0000-0002-4461-8756
Nuffield Dept of Primary Care Health Sciences Radcliffe Observatory Quarter, Woodstock Road
Research groups
Colleges
Websites
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Twitter
@jamessheppard48
James Sheppard
Ph.D. BSc(Hons), PGCert
Associate Professor
- Wellcome Trust/Royal Society Sir Henry Dale Fellow
- NIHR Oxford BRC Senior Fellow
I am a Population Health Scientist interested in better understanding the benefits and harms of treatments, with a particular focus on cardiovascular disease prevention. My research aims to develop tools which improve the targeting of preventative therapies such as antihypertensives and statins at patients with the most to gain.
I lead the Stratified TreAtments Research (STAR) Group which uses data from routine electronic health records to better understand the association between treatment and harms. Our work uses prognostic modelling techniques to predict those patients who are most likely to benefit and those most likely to suffer harm from these treatments. We also undertake systematic reviews of adverse events associated with treatment and randomised controlled trials of targeted deprescribing in older patients, including the OPTiMISE trial.
My previous work has involved developing a clinical prediction tool for PRedicting Out-of-OFfice Blood Pressure (PROOF-BP) to enable targeting of ambulatory blood pressure monitoring in primary care. I teach on the Evidence Based Medicine MSc degree programme, am deputy for the department's Athena Swan initiative and Secretary of the British and Irish Hypertension Society.
Key publications
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Journal article
Sheppard JP. et al, (2020), JAMA - Journal of the American Medical Association, 323, 2039 - 2051
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Journal article
Albasri A. et al, (2021), The BMJ, 372
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Journal article
Cai T. et al, (2021), The BMJ, 374
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Journal article
Sheppard JP. et al, (2023), PLOS Medicine, 20, e1004223 - e1004223
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Journal article
Archer L. et al, (2022), BMJ (Clinical research ed.), 379
Recent publications
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Journal article
Wade J. et al, (2023), Trials, 24
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Strategies for identifying patients for deprescribing of blood pressure medications in routine practice: An evidence review
Journal article
SHEPPARD J. and MCMANUS R., (2023), Hypertension
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Journal article
Koshiaris C. et al, (2023), The British journal of general practice : the journal of the Royal College of General Practitioners, 73, e605 - e614
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Journal article
Clark C. et al, (2023), The British journal of general practice : the journal of the Royal College of General Practitioners, 73
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Blood pressure in older people after a diagnosis of hypertension
Journal article
SHEPPARD J. and MCMANUS R., (2023), BMJ: British Medical Journal