Contact information
Research groups
Colleges
José Leal
Associate Professor in Health Economics
My research focuses on using real-world health data and clinical trials to show what works and what offers best value for patients and the NHS. Budgets are tight; smart choices save lives and money.
I build disease models and run economic studies using trials and registries across cardiovascular disease, diabetes, dementia, musculoskeletal care, mental health and eye health.
My findings inform national and European guidance and support work on the European Commission’s cardiovascular strategy. I lead studies with the European Society of Cardiology and serve as health economics lead on NIHR and ARUK programmes. I teach and supervise DPhil students interested in Health Economics.
I am an Associate Professor in Oxford’s Nuffield Department of Primary Care Health Sciences and serve on the NIHR RfPB committee.
Key publications
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Home-based rehabilitation programme compared with traditional physiotherapy for patients at risk of poor outcome after knee arthroplasty: The CORKA randomised controlled trial
Journal article
Barker KL. et al, (2021), BMJ Open, 11
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Prediction of mortality and major cardiovascular complications in type 2 diabetes: External validation of UK Prospective Diabetes Study outcomes model version 2 in two European observational cohorts
Journal article
Pagano E. et al, (2021), Diabetes, Obesity and Metabolism, 23, 1084 - 1091
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Economic burden of malignant blood disorders across Europe: a population-based cost analysis
Journal article
Burns R. et al, (2016), The Lancet Haematology, 3, e362 - e370
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The economic burden of cancer, coronary heart disease, dementia, and stroke in England in 2018, with projection to 2050: an evaluation of two cohort studies
Journal article
Landeiro F. et al, (2024), The Lancet Healthy Longevity, 5, e514 - e523
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Decision models of prediabetes populations: A systematic review
Journal article
Leal J. et al, (2019), Diabetes, Obesity and Metabolism, 21, 1558 - 1569
Recent publications
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Association between non-invasive biomarkers and quality of life in primary sclerosing cholangitis
Journal article
Dai J. et al, (2025), PLoS ONE
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Ten Year Follow-Up of a Multicentre Randomised Controlled Trial Assessing Clinical and Cost Effectiveness of Total Versus Partial Knee Replacement (TOPKAT)
Journal article
BEARD D., (2025), The Lancet Rheumatology
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Real-world waitlist randomised controlled trial of gameChange VR to treat severe agoraphobic avoidance in patients with psychosis: A study protocol
Journal article
Freeman D. et al, (2025), BMJ Open, 15
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Effects of empagliflozin on quality of life and healthcare use and costs in chronic kidney disease: a health economic analysis of the EMPA-KIDNEY trial
Journal article
Zhou J. et al, (2025), Eclinicalmedicine, 85
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Efficacy of a 6-month supported online programme (Feeling Safer) for the treatment of persecutory delusions: protocol for a randomised controlled trial
Journal article
Freeman D. et al, (2025), BMJ Open, 15