Contact information
Research groups
Colleges
José Leal
Associate Professor in Health Economics
My research focuses on using real-world health data and clinical trials to show what works and what offers best value for patients and the NHS. Budgets are tight; smart choices save lives and money.
I build disease models and run economic studies using trials and registries across cardiovascular disease, diabetes, dementia, musculoskeletal care, mental health and eye health.
My findings inform national and European guidance and support work on the European Commission’s cardiovascular strategy. I lead studies with the European Society of Cardiology and serve as health economics lead on NIHR and ARUK programmes. I teach and supervise DPhil students interested in Health Economics.
I am an Associate Professor in Oxford’s Nuffield Department of Primary Care Health Sciences and serve on the NIHR RfPB committee.
Recent publications
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Association between non-invasive biomarkers and quality of life in primary sclerosing cholangitis
Journal article
Dai J. et al, (2025), PLoS ONE
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Ten Year Follow-Up of a Multicentre Randomised Controlled Trial Assessing Clinical and Cost Effectiveness of Total Versus Partial Knee Replacement (TOPKAT)
Journal article
BEARD D., (2025), The Lancet Rheumatology
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Real-world waitlist randomised controlled trial of gameChange VR to treat severe agoraphobic avoidance in patients with psychosis: A study protocol
Journal article
Freeman D. et al, (2025), BMJ Open, 15
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Effects of empagliflozin on quality of life and healthcare use and costs in chronic kidney disease: a health economic analysis of the EMPA-KIDNEY trial
Journal article
Zhou J. et al, (2025), Eclinicalmedicine, 85
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Efficacy of a 6-month supported online programme (Feeling Safer) for the treatment of persecutory delusions: protocol for a randomised controlled trial
Journal article
Freeman D. et al, (2025), BMJ Open, 15