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Ly-Mee Yu

M.Sc., DPhil


Professor of Clinical Trials and Biostatistics

  • Co-Director of Primary Care Clinical Trials Unit
  • Co-Director of the NIHR Research Support Service (RSS) Hub and Specialist Centre for Public Health (hosted by Southampton)

I joined the Department in 2013 after previously working at the Centre for Statistics in Medicine where I led a team of statisticians, collaborating on a variety of clinical studies (predominately randomised controlled trials) and supported numerous funding applications (e.g. NIHR, FP7, MRC, and Wellcome Trust).  I have over 30 years of experience as a medical statistician and specifically in clinical trials for the past 20 years.  I have worked in a wide range of clinical areas, including but not limited to, renal disease, behavioural medicine, vaccinology, cardiovascular medicine, infectious disease, surgery, allied health, mental health, neurosciences, respiratory, and orthopaedics.  I have published over 200 articles in peer-reviewed journals such as the Lancet, JAMA and the BMJ.  I am currently the lead statistician of two platform adaptive decentralised clinical trials to evaluate treatment for COVID-19 in the community.

I am currently a Co-Director the Primary Care Clinical Trials Unit (CTU), and Co-Director of the NIHR Research Support Services (hosted by Southampton).  I am a panel member of the NIHR  Research Programme for Social Care and the Definitive Interventions and Feasibility Awards (HRB Ireland). I am also a member of the CHM Cancer Vaccines Expert Working Group (CVEWG).  I have sat on various NIHR funding boards and the Oxford Tropical Research Ethnics Committee. I am also a chair/member of data and safety monitoring committee, and the trial steering committee of several national and international trials.

My research interests include trial methodology, such as platform trials, decentralised clinical trials, missing data, covariate adjustment in clinical trials.

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