CARRii Publications

Explore the latest research, reports, and evidence-based insights from across the CARRii network — including peer-reviewed papers, policy briefs, white papers, and more. This page will serve as a central hub for all CARRii-affiliated publications.

Coming soon!...

August

July

June

• Point-of-care testing reduces antibiotic prescribing in acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis.
  Li X, Qiu S, Liu C, Zhao M, Yang X, Xia H, Wang R, Chen S, Chen J, Zheng J, Liu G, Yang S, Yang L, Butler CC.Int J Infect Dis. 2025 Jun;155:107889. doi: 10.1016/j.ijid.2025.107889. Epub 2025 Mar 19.PMID: 40113161 Free article.

May

• Characteristics of influenza, SARS-CoV-2, and RSV surveillance systems that utilise ICD-coded data: a systematic review.
  Agyei-Manu E, Atkins N, Nundy M, St-Jean C, Gornall-Wick A, Birley E, De Silva U, Krishan P, Vokey L, Dozier MF, McSwiggan E, McQuillan R, Theodoratou E, Shi T; UNCOVER Applied Evidence Synthesis group.J Glob Health. 2025 May 23;15:04177. doi: 10.7189/jogh.15.04177.PMID: 40406976 Free PMC article. 

• Exploring the disease experience and supportive care for people with very severe chronic obstructive pulmonary disease in Malaysia: a multiperspective qualitative study.
  Lim ZN, Liew SM, Khoo EM, Pinnock H, McCarthy S, Nathan JJ, Pang YK, Hanafi NS, Hussein N, Abu Bakar AI, Chan YL, Sheikh A; RESPIRE Collaboration.J Glob Health. 2025 May 23;15:04127. doi: 10.7189/jogh.15.04127.PMID: 40406983 Free PMC article.

• Impact of climate change and associated weather extremes on primary care in England among people with multiple long-term conditions.
  Tiwari R, Simpson G, Smith L, Holt S, Little P, Santer M, Lloyd J, Dambha-Miller H.Br J Gen Pract. 2025 May 22;75(suppl 1):bjgp25X741693. doi: 10.3399/bjgp25X741693. Print 2025 May.PMID: 40404449

• A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma.
  Joulia R, Patti S, Traves WJ, Loewenthal L, Yates L, Walker SA, Puttur F, Al-Sahaf M, Cahill KN, Lai J, Siddiqui S, Boyce JA, Israel E, Lloyd CM.Nat Immunol. 2025 May 21. doi: 10.1038/s41590-025-02161-3. Online ahead of print.PMID: 40399607

• Global Trends in the Relationship Between Chronic Air Pollution Exposure, Physical Activity and Lung Function in Youth Aged 5-18 Years With and Without Asthma: A Systematic Review.
  Gudziunaite S, Mackintosh KA, Davies GA, Jordan KA, Lewis PD, Griffiths CJ, Alexander Swain T, McNarry MA.Sports Med Open. 2025 May 21;11(1):57. doi: 10.1186/s40798-025-00856-3.PMID: 40399510 Free PMC article.

• 'Treat-to-target': a call for earlier targeted intervention in asthma.
  Couillard S, Pavord I, Hoyte F, Siddiqui S, Martin N, Menzies-Gow A, Lommatzsch M.J Allergy Clin Immunol Pract. 2025 May 13:S2213-2198(25)00436-2. doi: 10.1016/j.jaip.2025.05.012. Online ahead of print.PMID: 40373871

• Artificial Intelligence-generated answers to patients' questions on asthma: the AIR-Asthma study.Nigro M, Aliverti A, Angelucci A, Braido F, Canonica GW, Bossios A, Pinnock H, Boyd J, Powell P, Aliberti S; AIR-Asthma Task Force.J Allergy Clin Immunol Pract. 2025 May 7:S2213-2198(25)00420-9. doi: 10.1016/j.jaip.2025.04.051. Online ahead of print.PMID: 40345326

• The 2023 Garrod Lecture: Antimicrobial use and stewardship in primary care: what works, and what next?
  Little P.J Antimicrob Chemother. 2025 May 2;80(5):1207-1212. doi: 10.1093/jac/dkaf053.PMID: 40205913 Free PMC article. No abstract available.

• Optimizing adherence to medication to improve outcomes in asthma.
  Rackow P, Drennan A, Pinnock H, Dima AL.Curr Opin Pulm Med. 2025 May 1;31(3):262-269. doi: 10.1097/MCP.0000000000001166. Epub 2025 Mar 19.PMID: 40105049 Free PMC article. Review.

April

• Effectiveness of an online asthma education program in adults with asthma in general practice: Results from a cluster randomised controlled trial.
  Eck S, Baumgärtel A, Hapfelmeier A, Linde K, Sanftenberg L, Stark S, Schultz K, McClatchey K, Pinnock H, Schneider A; Bavarian Practice-Based Research Network (BayFoNet).Respir Med. 2025 Apr-May;240:108041. doi: 10.1016/j.rmed.2025.108041. Epub 2025 Mar 13.PMID: 40089038 Free article. Clinical Trial.

• A qualitative process evaluation of a nasal spray intervention to prevent respiratory tract infections.
  Dennis A, Joseph J, Greenwell K, Miller S, Vennik J, Dennison L, Holt S, Bradbury K, Geraghty AWA, Little P, Yardley L.PLoS One. 2025 Apr 29;20(4):e0321314. doi: 10.1371/journal.pone.0321314. eCollection 2025.PMID: 40299893 Free PMC article.

• Moderators' Experiences of the Safety and Effectiveness of Patient Engagement in an Asthma Online Health Community: Exploratory Qualitative Interview Study.
  Wood HE, Karampatakis GD, Coulson NS, Sastry N, Li X, Taylor SJC, Griffiths CJ, De Simoni A.J Med Internet Res. 2025 Apr 25;27:e58167. doi: 10.2196/58167.PMID: 40279577 Free PMC article.

• Development and validation of a machine learning risk prediction model for asthma attacks in adults in primary care.
  Tibble H, Sheikh A, Tsanas A.NPJ Prim Care Respir Med. 2025 Apr 23;35(1):24. doi: 10.1038/s41533-025-00428-8.PMID: 40268974 Free PMC article.

• The effect of a GP's perception of a patient request for antibiotics on antibiotic prescribing for respiratory tract infections: secondary analysis of a point-prevalence audit survey in 18 European countries.
  Domen J, Aabenhus R, Balan A, Bongard E, Böhmer F, Bralić Lang V, Bruno P, Chlabicz S, Colliers A, García-Sangenís A, Ghazaryan H, Kowalczyk A, Jensen S, Lionis C, van der Linde TM, Malania L, Pauer J, Tomacinschii A, Vellinga A, Zastavnyy I, Goossens H, Butler CC, van der Velden AW, Coenen S.BJGP Open. 2025 Apr 22:BJGPO.2024.0166. doi: 10.3399/BJGPO.2024.0166. Online ahead of print.PMID: 39824603 Free article.

• Are acute asthma presentations to the emergency department an opportunity for optimising long-term management? A qualitative study on beliefs and behaviours of healthcare professionals.
  Skene I, Griffiths C, Pike K, Bloom BM, Pfeffer P, Steed L.Emerg Med J. 2025 Apr 16:emermed-2024-214407. doi: 10.1136/emermed-2024-214407. Online ahead of print.PMID: 40240076 Free article.

• Effect modification and interaction between ethnicity and socioeconomic factors in severe COVID-19: analyses of linked national data for Scotland.
  McCabe R, Kibuchi E, Amele S, Irizar P, Sheikh A, Jeffrey K, Ruden I, Simpson CR, McCowan C, Ritchie L, Robertson C, Leyland AH, Demou E, Pearce A, Katikireddi SV.BMJ Open. 2025 Apr 14;15(4):e092727. doi: 10.1136/bmjopen-2024-092727.PMID: 40228847 Free PMC article.

• Democratising clinical trials research to strengthen primary health care.
  Butler CC, Mash R, Gobat N, Little P, Makasa M, Makwero M, Mills EJ, Sit RW, Bachmann MO.Lancet Glob Health. 2025 Apr;13(4):e749-e758. doi: 10.1016/S2214-109X(24)00513-8.PMID: 40155112 Free PMC article. Review.

• Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission-Longitudinal (UNIVERSAL) study: a prospective observational cohort study protocol.
  Morelli T, Purcell M, Rodrigues P, Roberts C, Cox O, Lee PH, Thorne K, Allen A, Cazaly A, Nuttall J, Raftery J, Griffiths G, Cook A, White N, Greening NJ, Pavitt M, Myerson J, Marciniak SJ, Daneshvar C, Crooks MG, Mitchelmore P, Chalmers JD, Siddiqui S, Staples KJ, Clark TW, Freeman A, Wilkinson T; UNIVERSAL Study group.BMJ Open. 2025 Apr 9;15(4):e093427. doi: 10.1136/bmjopen-2024-093427.PMID: 40204301 Free PMC article.

• Incidence and prevalence of asthma, chronic obstructive pulmonary disease and interstitial lung disease between 2004 and 2023: harmonised analyses of longitudinal cohorts across England, Wales, South-East Scotland and Northern Ireland.
  Whittaker H, Kramer Fiala Machado A, Hatam S, Cook S, Scully S, Evans HTT, Bolton T, Kallis C, Busby J, Heaney LG, Sheikh A, Quint JK; CVD-COVID-UK/COVID-IMPACT Consortium.Thorax. 2025 Apr 8:thorax-2024-222699. doi: 10.1136/thorax-2024-222699. Online ahead of print.PMID: 40199588 Free article.

• Assessment of an Oral Corticosteroid Withdrawal Pathway for Severe Asthma Patients Receiving Biologic Therapies.Aung HWW, Russell RJ, Boddy CE, Balasundaram K, Hampson E, Bell M, Parnell LA, Bonnington MA, Mohammad S, Levy M, Meeran K, Siddiqui S, Naveed S, Bradding P.J Allergy Clin Immunol Pract. 2025 Apr 8:S2213-2198(25)00313-7. doi: 10.1016/j.jaip.2025.03.048. Online ahead of print.PMID: 40209926 Free article.

• The COVID-19 pandemic in children and young people during 2022-24: what new did we learn?
  Rudan I, Kerr S, Simpson CR, Kurdi A, Adeloye D, Robertson C, Sheikh A; EAVE II Collaboration.J Glob Health. 2025 Apr 2;15:01002. doi: 10.7189/jogh.15.01002.PMID: 40168509 Free PMC article. Review.

• Are ethnic inequalities in COVID-19 outcomes mediated by occupation risk? Analyses of a 2-year record linked national cohort study in Scotland.
  Kibuchi E, Amele S, McCabe R, Demou E, Leyland AH, Simpson CR, Shi T, Irizar P, Becares L, Sheikh A, Pearce A, Katikireddi SV.Eur J Public Health. 2025 Apr 1;35(2):379-385. doi: 10.1093/eurpub/ckaf025.PMID: 40044144 Free PMC article.

• A viro-immunological model to characterize the antiviral effect of molnupiravir in SARS-CoV-2-infected outpatients: implication for treatment duration.
  Nguyen BT, Bertrand J, Agyeman AA, Zhang S, Yu LM, Harris V, Little P, Butler CC, Breuer J, Lowe DM, Standing JF, Guedj J; PANORAMIC study group.J Infect Dis. 2025 Apr 1:jiaf158. doi: 10.1093/infdis/jiaf158. Online ahead of print.PMID: 40167341

March

• Saline nasal irrigation for acute sinusitis (SNIFS II): a randomised controlled pilot trial with nested process evaluation.
  Venekamp RP, Ainsworth B, Thomas T, Stuart B, Slodkowska-Barabasz J, Mowbray F, Butler CC, Francis N, Richards-Hall S, Harnden A, Hay AD, Hopkins C, Moore M, Yardley L, Verheij TJ, Zhu S, Little P.BJGP Open. 2025 Mar 31:BJGPO.2024.0307. doi: 10.3399/BJGPO.2024.0307. Online ahead of print.PMID: 40164493 Free article.

• Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma.
  Khaleva E, Brightling C, Eiwegger T, Altraja A, Bégin P, Blumchen K, Bossios A, Bourdin A, Ten Brinke A, Brusselle G, Bumbacea RS, Bush A, Casale TB, Clarke GW, Chaudhuri R, Chung KF, Coleman C, Corren J, Dahlén SE, Deschildre A, Djukanovic R, Eger K, Exley A, Fleming L, Fowler SJ, Gaillard EA, Gappa M, Gupta A, Haitchi HM, Hashimoto S, Heaney LG, Hedlin G, Henderson M, Hua W, Jackson DJ, Karadag B, Katelaris CH, Koh MS, Kopp MV, Koppelman GH, Kull I, Kurukulaaratchy RJ, Lee JH, Mahler V, Mäkelä M, Masoli M, Mathioudakis AG, Mazon A, Melén E, Milger K, Moeller A, Murray CS, Nagakumar P, Nair P, Negus J, Nieto A, Papadopoulos NG, Paton J, Pijnenburg MW, Pike KC, Porsbjerg C, Rattu A, Rupani H, Rusconi F, Rutjes NW, Saglani S, Seddon P, Siddiqui S, Singer F, Tajiri T, Turner S, Upham JW, Vijverberg SJH, Wark PAB, Wechsler ME, Yasinska V, Roberts G; 3TR Asthma Definition of Response Working Group.Eur Respir J. 2025 Mar 27;65(3):2400691. doi: 10.1183/13993003.00691-2024. Print 2025 Mar.PMID: 39510551 Free PMC article.

• Rapid microbiological respiratory point-of-care testing: a qualitative study with primary care clinicians.Clarke R, Brown E, Hay AD, Mitchell PM, Ridd MJ, Zhu L, Yardley L.Br J Gen Pract. 2025 Mar 27;75(753):e241-e249. doi: 10.3399/BJGP.2024.0413. Print 2025 Apr.PMID: 39740928 Free PMC article. Clinical Trial.

• Correction: Implementing digital respiratory technologies for people with respiratory conditions: A protocol for a scoping review.
  Hui CY, Condon K, Kolekar S, Roberts N, Sreter KB, Simons SO, Figueiredo C, McKeough Z, Salim H, Gawlik-Lipinski A, Gonsard A, Aral AÖ, Vanoverschelde A, Armstrong M, Kohlbrenner D, Paixão C, Stafler P, Papadopoulou E, Rabe AP, Mohammad M, Bouloukaki I, Quach S, Chaabouni M, Kaltsakas G, Loveys K, Reier-Nilsen T, Sunjaya AP, Robinson P, Pinnock H, Chan AHY.PLoS One. 2025 Mar 27;20(3):e0321228. doi: 10.1371/journal.pone.0321228. eCollection 2025.PMID: 40146769 

• Readability and complexity of written information presented to hospitalised patients for trial consent during the COVID-19 pandemic in the UK: a retrospective document analysis.
  Gourlay E, Felton T, Bafadhel M, Brightling CE, Davies JC, Evans RA, Ho LP, Marciniak SJ, Maskell NA, Porter J, Sapey E, Siddiqui S, Walker S, Wilkinson T, Horsley AR.BMJ Open. 2025 Mar 21;15(3):e089447. doi: 10.1136/bmjopen-2024-089447.PMID: 40118493 Free PMC article.

• COVER-ME: developing and evaluating community-based interventions to promote vaccine uptake for COVID-19 and influenza in East London minority ethnicity (ME) and underserved individuals - protocol for a pilot randomised controlled trial.Chaudhry T, Tum P, Tam HZ, Brentnall A, Smethurst H, Kielmann K, Kunst H, Hargreaves S, Campbell CNJ, Griffiths C, Zenner D.BMJ Open. 2025 Mar 18;15(3):e092568. doi: 10.1136/bmjopen-2024-092568.PMID: 40107676 Free PMC article.

• Exogenous sex steroid hormones and asthma phenotypes: a study protocol for a prospective cohort analysis with UK-wide primary care data.
  Almaghrabi F, Nwaru BI, Sheikh A, Tsanas A, Tibble H, Critchley H, Jackson T, Ali A, Shah SA.BMJ Open. 2025 Mar 13;15(3):e097126. doi: 10.1136/bmjopen-2024-097126.PMID: 40081993 Free PMC article.

• Medication nonadherence - definition, measurement, prevalence, and causes: reflecting on the past 20 years and looking forwards.
  Chapman SCE, Chan AHY.Front Pharmacol. 2025 Mar 7;16:1465059. doi: 10.3389/fphar.2025.1465059. eCollection 2025.PMID: 40124783 Free PMC article. Review.

• London's Ultra Low Emission Zone and active travel to school: a qualitative study exploring the experiences of children, families and teachers.
  Alliott O, van Sluijs E, Dove R, Kalsi H, Mitchell J, Mudway I, Randhawa G, Sartori L, Scales J, Wood HE, Griffiths C, Guell C, Panter J.BMJ Open. 2025 Mar 3;15(3):e091929. doi: 10.1136/bmjopen-2024-091929.PMID: 40032382 Free PMC article.

• Medication adherence-Everybody's problem but nobody's responsibility?
  Chan AHY, Wright DFB.Br J Clin Pharmacol. 2025 Mar;91(3):681-683. doi: 10.1111/bcp.16384. Epub 2024 Dec 29.PMID: 39734279 No abstract available.

February

• CARRii White Paper - click to download

January

• Impact of COVID-19 pandemic on elective care backlog trends, recovery efforts, and capacity needs to address backlogs in Scotland (2013-2023): a descriptive analysis and modelling study.
  Shah SA, Jeffrey K, Robertson C, Sheikh A.Lancet Reg Health Eur. 2025 Jan 9;50:101188. doi: 10.1016/j.lanepe.2024.101188. eCollection 2025 Mar.PMID: 40093393 Free PMC article.