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  1. Gather information about people’s blood pressure measured in routine clinical practice and recorded in their medical records.
  2. Examine novel strategies for the diagnosis and management of high blood pressure.

Why this is important:

High blood pressure (hypertension) affects over 900 million people across the world. It is an important risk factor for heart attacks or stroke which are the leading cause of death and disability worldwide. The diagnosis and management of hypertension depends on accurate measurement of blood pressure in order to target treatment appropriately and avoid unnecessary healthcare costs. Current strategies for the diagnosis and management of hypertension are sub-optimal and can lead patients being given the wrong treatments to manage their blood pressure.


The aim of the PROOF-ABPM study is to set up a prospective register of all patients undergoing blood pressure screening in GP surgeries and hospitals. Data contained within the register will include patient characteristics, repeated office and 24 hour ambulatory blood pressure, clinical assessment data and subsequent admissions to hospital.
The study will recruit 1000 patients from GP surgeries and hospitals. Patients will be eligible for the study if they are aged 18 years or older and have been referred by their doctor for routine 24 hour ambulatory blood pressure monitoring. Those giving informed consent will be asked for permission to let the research team store personal information (name, address, date of birth, NHS number) and link it to information about the participant’s blood pressure and medical history.

How this could benefit patients:

The PROOF-ABPM will explore the most efficient way of screening patient’s blood pressure using standard blood pressure measurement techniques and along with more detailed 24 hour ambulatory blood pressure monitoring. Information gathered within the database will be used to test new strategies which allow doctors to target the most detailed monitoring at patients with the most to gain. Improved targeting of blood pressure monitoring could lead to more appropriate diagnosis and treatment of hypertension, and thus reduced risk of heart attack and stroke.

Full project title: 

Prospective Register Of patients undergoing repeated OFfice and Ambulatory Blood Pressure Monitoring (PROOF-ABPM)

Length of project:

2.5 years

Funded by:

Medical Research Council Logo

External collaborators:

Technical summary/trial protocol:

Study resources

Further links:

PROOF-ABPM - Primary Care Clinical Trials Unit
CRN portfolio page